Changes in mediators of inflammation and pro-thrombosis after 12 months of dietary modification in adults with metabolic syndrome
| Autor: | O E Oyewole, Sheu Kadiri Rahamon, O. Hassan, E. O. Agbedana, M. O. Ebesunun, J. A. Olaniyi, Adesoji Adedipe Fasanmade, B M Ajobo, J. R. Adebusuyi, M A Charles-Davies, O. O. Popoola, K. S. Akinlade, U A Fabian, Mayowa O. Owolabi, W Omiyale, K Adigun, Olatunbosun Ganiyu Arinola |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Blood Glucose Male medicine.medical_specialty Calorie Waist Nigeria 030204 cardiovascular system & hematology Fibrinogen 03 medical and health sciences 0302 clinical medicine Internal medicine Plasminogen Activator Inhibitor 1 medicine Humans Longitudinal Studies Dietary modification fibrinogen interleukins metabolic syndrome plasminogen activator inhibitor Triglycerides Inflammation Metabolic Syndrome business.industry Interleukin-6 Cholesterol HDL Thrombosis General Medicine Articles Carbohydrate Anthropometry Middle Aged medicine.disease Diet Interleukin-10 030104 developmental biology Endocrinology Blood pressure Cholesterol Female Metabolic syndrome Waist Circumference business Plasminogen activator medicine.drug |
| Zdroj: | African Health Sciences; Vol 17, No 2 (2017); 453-462 |
| ISSN: | 1680-6905 |
| Popis: | Objective: This study evaluated the effects of a 12-month dietary modification on indices of inflammation and pro-thrombosis in adults with metabolic syndrome (MS). Materials and methods: This longitudinal study involved 252 adults with MS recruited from the Bodija market, Ibadan and its environs. Participants were placed on 20%, 30% and 50% calories obtained from protein, total fat and carbohydrate respectively and were followed up monthly for 12 months. Anthropometry and blood pressure were measured using standard methods. Fasting plasma glucose (FPG), total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C), fibrinogen, plasminogen activator inhibitor-1 (PAI-1)], interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured using spectrophotometric methods and ELISA as appropriate. Data was analysed using ANCOVA, Student’s t -test, Mann-Whitney U and Wilcoxon signed-rank tests. P -values less than 0.05 were considered significant. Results: After 6 months of dietary modification, there was a significant reduction in waist circumference (WC), while the levels of HDL-C, fibrinogen and PAI-1 were significantly increased when compared with the corresponding baseline values. However, WC and fibrinogen reduced significantly, while HDL-C and IL-10 significantly increased after 12 months of dietary modification as compared with the respective baseline values. Conclusion: Long-term regular dietary modification may be beneficial in ameliorating inflammation and pro-thrombosis in metabolic syndrome. Keywords: Dietary modification, fibrinogen, interleukins, metabolic syndrome, plasminogen activator inhibitor |
| Databáze: | OpenAIRE |
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