Biomarker responses (serum biochemistry) in pregnant female wistar rats and histopathology of their neonates exposed prenatally to pesticides
| Autor: | Jyoti Upadhyay, Satpal Singh Bisht, Amita Rana, Vijay Juyal, Mahendra Rana, Sumit Durgapal |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pesticide exposure/ histopathology
medicine.medical_specialty Bilirubin lcsh:RS1-441 Blood sugar Physiology 030226 pharmacology & pharmacy 01 natural sciences lcsh:Pharmacy and materia medica 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Blood serum Medicine Pesticide residue Carbendazim business.industry Pesticide 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Newborn/ histopathology Glyphosate Carbendazim Biomarker (medicine) Histopathology Pesticide exposure/histopathology sense organs Biomarkers/ analysis Biomarker responses business Herbicides/ toxicity |
| Zdroj: | Brazilian Journal of Pharmaceutical Sciences, Vol 55 Brazilian Journal of Pharmaceutical Sciences, Volume: 55, Article number: e18194, Published: 10 JUL 2019 Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e18194 Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e18194 Brazilian Journal of Pharmaceutical Sciences Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 2175-9790 1984-8250 |
| DOI: | 10.1590/s2175-97902019000118194 |
| Popis: | Experiments were conducted to investigate the effects on health of pregnant female rats exposed to pesticides glyphosate and carbendazim. Glyphosate is used as herbicide and carbendazim as a fungicide; all are commercially available readily for various agricultural and domestic purposes. The hypothesis tested in this investigation is that pesticide exposure during pregnancy causes changes in biomarker responses like serum glucose level, total protein, total cholesterol, triglycerides, SGOT, SGPT, and billirubin level. Significant changes were observed in all above biomarker responses, when compared with the reference. Histopathology of skin and kidney of rat neonates showed marked damage. Degenerative changes and vacuolization with eroded capsule were observed in kidney sample and thinning of epidermis in skin sample was seen in pesticides exposed neonates of rats. The serum biochemistry and histopathological findings are valuable markers for observing the changes caused by pesticide exposure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|