Cerebrospinal Fluid Viral Load Across the Spectrum of Untreated Human Immunodeficiency Virus Type 1 (HIV-1) Infection: A Cross-Sectional Multicenter Study
| Autor: | Amy Lin, Paola Cinque, Carmela Pinnetti, Valeria De Zan, Alan Winston, Andrea Calcagno, Gustaf Ulfhammer, Bruce J Brew, Arvid Edén, Staffan Nilsson, Cristiana Oprea, Mattia Trunfio, Lars Hagberg, Andrea Antinori, Richard W. Price, Magnus Gisslén, Serena Spudich |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Microbiology (medical) medicine.medical_specialty AIDS Dementia Complex Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause Neopterin Gastroenterology chemistry.chemical_compound Cerebrospinal fluid Central Nervous System Diseases Albumins Internal medicine White blood cell medicine Humans Cerebrospinal Fluid business.industry Albumin Viral Load Cross-Sectional Studies Infectious Diseases medicine.anatomical_structure Multicenter study chemistry Multi center study HIV-1 RNA Viral business Viral load |
| Zdroj: | Clinical Infectious Diseases. 75:493-502 |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | Background The aim of this large multicenter study was to determine variations in cerebrospinal fluid (CSF) HIV-RNA in different phases of untreated human immunodeficiency virus type 1 (HIV-1) infection and its associations with plasma HIV-RNA and other biomarkers. Methods Treatment naive adults with available CSF HIV-RNA quantification were included and divided into groups representing significant disease phases. Plasma HIV-RNA, CSF white blood cell count (WBC), neopterin, and albumin ratio were included when available. Results In total, 1018 patients were included. CSF HIV-RNA was in median (interquartile range [IQR]) 1.03 log10 (0.37–1.86) copies/mL lower than in plasma, and correlated with plasma HIV-RNA (r = 0.44, P plasma discordance was found in 126 of 972 individuals (13%) and varied between groups, from 1% in primary HIV, 11% in neuroasymptomatic groups, up to 30% of patients with HAD. Conclusions Our study confirms previous smaller observations of variations in CSF HIV-RNA in different stages of HIV disease. Overall, CSF HIV-RNA was approximately 1 log10 copies/mL lower in CSF than in plasma, but CSF discordance was found in a substantial minority of subjects, most commonly in patients with HAD, indicating increasing CNS compartmentalization paralleling disease progression. |
| Databáze: | OpenAIRE |
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