| Autor: |
Annie Ouellet, Prakesh S. Shah, Lannae Strueby, James Andrews, Graeme N. Smith, Ermelinda Pelausa, Guillaume Ethier, Lara Wesson, Stephen J. Wood, Candace O’Quinn, Kyong-Soon Lee, Christine Drolet, Amy Metcalfe, Hayley Boss, Khalid Aziz, Zenon Cieslak, Jason Burrows, Jagdeep Ubhi, Michelle Morais, Luis Monterrosa, Anie Lapoint, Hala Makary, Karen Wou, Kimberly Butt, Andrzej Kajetanowicz, Ayman Abou Mehrem, Hemasree Kandraju, Leanne Dahlgren, Ruben Alvaro, Rob Gratton, Orlando da Silva, Sibasis Daspal, Jaya Bodani, Darine El-Chaar, Jaideep Kanungo, Christy Pylypjuk, Brigitte Lemyre, Carlos Fajardo, Marie St-Hilaire, Mohammad Adie, Marc Beltempo, Sue Chandra, Joseph Ting, Michael Helewa, Haim A. Abenhaim, Jehier Afifi, Julie Emberley, Ariadna Grigoriu, George Carson, Katherine Theriault, Faiza Khurshid, Vicky Allen, Bruno Piedboeuf, Fatima Taboun, Shoo K. Lee, Cecil Ojah, Rebecca Sherlock, Edith Masse, Xiang Y. Ye, Thierry Daboval, Eugene Ng, Joan Crane, Mary Seshia, Amit Mukerji, Catherine Taillefer, Isabelle Boucoiran, Erin MacLellan, Jon Dorling, Wendy Whittle, Valerie Bertelle, Nir Melamed, Deepak Louis, Martine Claveau, Jennifer Toye, Keith J. Barrington, Roderick Canning |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Paediatrics Publications |
| Popis: |
Objective: To evaluate the association of a combined exposure to antenatal steroids and prophylactic indomethacin with the outcome of spontaneous intestinal perforation (SIP) among neonates born at 7 days before birth) exposures. The co-exposure was prophylactic indomethacin. The primary outcome was SIP. Multivariable logistic regression analysis was used to calculate aORs. Results: Among 4720 eligible infants, 4121 (87%) received antenatal steroids and 1045 (22.1%) received prophylactic indomethacin. Among infants exposed to antenatal steroids, those who received prophylactic indomethacin had higher odds of SIP (aOR 1.61, 95% CI 1.14-2.28) compared with no prophylactic indomethacin. Subgroup analyses revealed recent antenatal steroids exposure with prophylactic indomethacin had higher odds of SIP (aOR 1.67, 95% CI 1.15-2.43), but latent antenatal steroids exposure with prophylactic indomethacin did not (aOR 1.24, 95% CI 0.48-3.21), compared with the respective groups with no prophylactic indomethacin. Among those not exposed to antenatal steroids, mortality was lower among those who received prophylactic indomethacin (aOR 0.45, 95% CI 0.28-0.73) compared with no prophylactic indomethacin. Conclusions: In preterm neonates of |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
