PROTEIN-BOUND IODINE DURING ANTITHYROID TREATMENT
| Autor: | L. Skovsted, J. Mølholm Hansen, L. Korsgaard Christensen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases Antithyroid drugs medicine.medical_treatment chemistry.chemical_element Thyroid Function Tests Iodine Hyperthyroidism Protein-bound iodine Iodine Radioisotopes Thyroxine-Binding Proteins Internal medicine Myxedema Internal Medicine medicine Humans Triiodothyronine business.industry Antithyroid agent Middle Aged Normal limit Endocrinology Basal (medicine) chemistry Propylthiouracil Thyroid hormones Female Basal Metabolism business |
| Zdroj: | Acta Medica Scandinavica. 185:483-487 |
| ISSN: | 0001-6101 |
| Popis: | A combination of low protein-bound iodine values and normal basal metabolic rates has been found in some thyrotoxic patients treated with antithyroid drugs. Experiments are presented which show that this observation can be explained by an increase in the triiodothyronine share of the circulating thyroid hormones in these patients. The finding of a low PBI value in an antithyroid-treated patient will in some cases not be an indication of myxoedema. It is suggested, however, that a low PBI value also in these patients is a sign of overtreatment. The practical outcome of these experiments and considerations, consequently, is that measurement of BMR values alone does not ensure adequate control during treatment with antithyroid agents. A determination of PBI values should be included and it is suggested that the dose of antithyroid compound is adjusted to keep the PBI within normal limits. |
| Databáze: | OpenAIRE |
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