Lower prefrontal activation during emotion regulation in subjects at ultrahigh risk for psychosis
| Autor: | Jorien van der Velde, Edith J. Liemburg, Richard Bruggeman, Roeline Nieboer, André Aleman, Esther M. Opmeer, Lex Wunderink |
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| Přispěvatelé: | Perceptual and Cognitive Neuroscience (PCN), Clinical Neuropsychology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Psychosis Ventrolateral prefrontal cortex medicine.diagnostic_test Brain activity and meditation Dysfunctional family medicine.disease Article Psychiatry and Mental health medicine.anatomical_structure Schizophrenia medicine Psychiatry Set (psychology) Psychology Functional magnetic resonance imaging International Affective Picture System Clinical psychology |
| Zdroj: | NPJ Schizophrenia NPJ Schizophrenia, 1:15026. SPRINGERNATURE |
| ISSN: | 2754-6993 |
| DOI: | 10.1038/npjschz.2015.26 |
| Popis: | Previous research has shown that patients with schizophrenia experience difficulties with emotion regulation and activate prefrontal regions to a lesser extent during reappraisal of emotional information. It has been suggested that problems in emotion regulation might precede the onset of psychosis. Therefore, it could be hypothesized that also individuals at ultrahigh risk (UHR) for developing psychosis experience difficulties with emotion regulation. The aim of the current study was to investigate whether individuals at UHR for developing psychosis show abnormal brain activation during reappraisal of negative pictures. Using functional magnetic resonance imaging (fMRI), we scanned 15 UHR participants and 16 matched healthy controls while performing an emotion regulation task. During this task, participants had to reappraise their negative emotion elicited by International Affective Picture System pictures. Furthermore, the reported use of reappraisal was examined with the emotion regulation questionnaire (ERQ). Individuals at UHR for psychosis showed less activation in the left ventrolateral prefrontal cortex during reappraisal compared with healthy controls. Furthermore, they reported less use of reappraisal in daily life (P=0.01; 95% CI (0.24–1.63)). These findings indicate that dysfunctional emotion regulation may already occur in individuals at risk for psychosis. These regulation difficulties are underpinned by less ventrolateral prefrontal cortex activation, and may result in high negative affect, lower social functioning, and high rates of psychotic symptoms. Individuals at high risk of developing psychosis may have problems regulating emotions, new research suggests. Noting that patients with schizophrenia are known to exhibit abnormal brain activation during emotion regulation, Jorien van der Velde at the University of Groningen, The Netherlands, and co-workers set their sights on patients who are at ultra-high risk (UHR) of psychosis—based on both genetic and psychological criteria—but have not yet developed symptoms. Using functional MRI, they compared brain activity during a picture assessment task in 15 UHR patients and 16 healthy controls. While viewing and reappraising negative and neutral images, UHR patients showed lower activation of the left ventrolateral prefrontal cortex, a part of the brain associated with moderating emotions. The study offers new data for understanding how psychoses develop and how they might be predicted. |
| Databáze: | OpenAIRE |
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