Zika virus infection in pregnancy
| Autor: | Marion Koopmans, Celina Maria Turchi Martelli, Moritz Pohl, Barry Rockx, Carlo Giaquinto, Maria Elisabeth Lopes Moreira, Ricardo Arraes de Alencar Ximenes, Demócrito de Barros Miranda-Filho, A E Ades, Ernesto T. A. Marques, Annelies Wilder-Smith, Jose Eduardo Gotuzzo H, Celia D. C. Christie, Carmen Soria Segarra, Paola Mariela Saba Villarroel, J. Glenn Morris, Kerstin D Rosenberger, Marília Dalva Turchi, Thomas Jaenisch, Adriana Tami, Antoni Soriano-Arandes, Bruno Hoen, Thália Velho Barreto de Araújo, Xavier de Lamballerie, Neal Alexander, David Brown, Patrícia Brasil, Vivian Iida Avelino-Silva, Víctor Hugo Borja Aburto, Maria Consuelo Miranda, Ulisses Ramos Montarroyos, Claire Thorne, Sarah Esperanza Bethencourt Castillo, Wayner Vieira de Souza, Mauro M. Teixeira, Elizabeth B. Brickley |
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| Přispěvatelé: | Virology |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microcephaly
Pediatrics Infektionsmedicin Global Health Zika virus Cohort Studies 0302 clinical medicine Pregnancy Epidemiology Flavivirus Infections Congenital Zika Syndrome 030212 general & internal medicine microcephaly Prospective Studies Pregnancy Complications Infectious Prospective cohort study biology Zika Virus Infection public health Infectious immunisation General Medicine 3. Good health Caribbean Region Meta-analysis Female epidemiology pregnancy Risk medicine.medical_specialty Infectious Medicine 030231 tropical medicine paediatric infectious disease & immunisation 03 medical and health sciences SDG 3 - Good Health and Well-being medicine paediatric infectious disease & Humans Latin America Zika Virus business.industry Public health biology.organism_classification medicine.disease Pregnancy Complications meta-analysis vertical transmission business |
| Zdroj: | BMJ Open Ades, A E, Thorne, C, Wilder-Smith, A & al., E 2020, ' Zika virus infection in pregnancy : A protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia ', BMJ Open, vol. 10, no. 12, e035307 . https://doi.org/10.1136/bmjopen-2019-035307 BMJ Open, 10(12):e035307. BMJ Publishing Group BMJ Open, 10(12):e035307. BMJ PUBLISHING GROUP |
| ISSN: | 2044-6055 |
| Popis: | IntroductionZika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laboratory markers of congenital infection in deliveries to women experiencing ZIKV infection during pregnancy, using data from European Commission-funded prospective cohort studies in 20 centres in 11 countries across Latin America and the Caribbean.Methods and analysisWe will carry out a centre-by-centre analysis of the risks of adverse pregnancy and birth outcomes, comparing women with confirmed and suspected ZIKV infection in pregnancy to those with no evidence of infection in pregnancy. We will document the proportion of deliveries in which laboratory markers of congenital infection were present. Finally, we will investigate the associations of trimester of maternal infection in pregnancy, presence or absence of maternal symptoms of acute ZIKV infection and previous flavivirus infections with adverse outcomes and with markers of congenital infection. Centre-specific estimates will be pooled using a two-stage approach.Ethics and disseminationEthical approval was obtained at each centre. Findings will be presented at international conferences and published in peer-reviewed open access journals and discussed with local public health officials and representatives of the national Ministries of Health, Pan American Health Organization and WHO involved with ZIKV prevention and control activities. |
| Databáze: | OpenAIRE |
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