Necrotizing enterocolitis in a neonatal piglet model
| Autor: | Timothy C. Counihan, Rodney A. Moxley, Ronald F. Martin, Ian T. Cohen, Michael P. Hirsh, Scarlett D. Nelson |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Swine Carotid arteries Core temperature Animal model Hypothermia Induced Intestine Small medicine Animals Hypoxia Enterocolitis Pseudomembranous business.industry General Medicine Hypoxia (medical) medicine.disease Surgery Disease Models Animal Animals Newborn Pediatrics Perinatology and Child Health Necrotizing enterocolitis Neonatal piglet Swine Miniature Pulmonary hemorrhage medicine.symptom business External jugular vein |
| Zdroj: | Journal of pediatric surgery. 26(5) |
| ISSN: | 0022-3468 |
| Popis: | The aim of this study was to develop an animal model for necrotizing enterocolitis (NEC). Twenty-five neonatal Hanford minipigs had carotid artery and external jugular vein catheters and rectal Clinical Tonomitors placed under anesthesia. Experimental animals were subjected to a hypoxic insult (50% reduction in baseline PaO2 for 30 minutes) and hypothermic stress (core temperature reduced to 35 degrees C for 30 minutes). Regular oral diet was resumed and the survivors were euthanized 3 to 4 days later. All animals underwent necropsy with gross and histopathological evaluation of the entire bowel. Of 22 experimental animals, 14 survived (64%) and 8 (36%) died of pulmonary hemorrhage. Of the 14 survivors, 8 (57%) had gross and microscopic evidence of NEC. Six of the total 25 animals (24%) sustained rectal perforations from the tonometer. Of 3 control animals, one died of pulmonary hemorrhage and the two survivors had normal intestine. This model successfully produced gross and histological evidence of NEC. The tonometer shows promise as a predictor of NEC provided technical modifications can reduce the complication rate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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