Peripheral neuropathy in hepatitis-related mixed cryoglobulinemia: Electrophysiologic follow-up study
| Autor: | Eduardo Ammendola, Giuseppe Di Iorio, A. Ammendola, Gianluca Ciccone, L. Ambrosone, Sergio Migliaresi, Simone Sampaolo |
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| Přispěvatelé: | Ammendola, A, Sampaolo, Simone, Ambrosone, L, Ammendola, E, Ciccone, G, Migliaresi, S, DI IORIO, Giuseppe |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Hepatitis C virus Interferon alpha-2 medicine.disease_cause Antiviral Agents Gastroenterology Cellular and Molecular Neuroscience Neuritis Rheumatoid Factor Prednisone Physiology (medical) Immunopathology Internal medicine medicine Humans Aged Retrospective Studies Hepatitis business.industry Vascular disease Interferon-alpha Peripheral Nervous System Diseases Complement C4 Hepatitis C Middle Aged medicine.disease Recombinant Proteins Surgery Electrophysiology Cross-Sectional Studies Peripheral neuropathy Cryoglobulinemia Immunoglobulin M Drug Therapy Combination Female Steroids Neurology (clinical) business Follow-Up Studies medicine.drug Kidney disease |
| Zdroj: | Muscle & Nerve. 31:382-385 |
| ISSN: | 1097-4598 0148-639X |
| DOI: | 10.1002/mus.20184 |
| Popis: | A retrospective study was performed on 27 patients with hepatitis C (HCV)-related mixed cryoglobulinemia (purpura, arthralgia, hepatitis, glomerulonephritis, peripheral neuropathy) to assess peripheral nerve involvement during follow-up of up to 8 years. All patients had the same degree of organ/system involvement initially and were clinically evaluated at least annually. All 27 patients received steroids; 15 also received recombinant interferon-alpha 2b (rIFN-alpha 2b). At first examination, neurological signs and electrodiagnostic findings consistent with peripheral neuropathy were found in 20 (74%) and in 24 (88.8%) patients, respectively. Neurological evaluation and electrodiagnostic data at 3 and 8 years revealed worsening of neuropathy, whereas the other manifestations of mixed cryoglobulinemia (MC) were stable. At the last examination, clinical and electrodiagnostic signs of neuropathy were found in 25 patients (92.5%), occurring in 1 of 3 patients with normal initial findings, and worsened in 8. A more severe neuropathy was observed in 3 (25%) of the patients treated with prednisone alone and in 6 (40%) of the patients additionally treated with rIFN-alpha 2b. Our data confirm that in patients with HCV-related MC, peripheral nerve involvement is frequent, is progressive, and does not seem to benefit by addition of rIFN-alpha 2b to steroid treatment. |
| Databáze: | OpenAIRE |
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