Oxidants and the pathophysiology of burn and smoke inhalation injury
| Autor: | Yeo-Kyu Youn, Robert H. Demling, Cheryl Lalonde |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Xanthine Oxidase
Free Radicals Inhalation Smoke Inhalation Injury Smoke inhalation Hemodynamics Physiology Oxidants medicine.disease Biochemistry Lipid peroxidation chemistry.chemical_compound Traumatic injury chemistry Physiology (medical) Anesthesia medicine Humans Lipid Peroxidation Animal studies Burns Xanthine oxidase Lung Chemical Injury |
| Zdroj: | Free Radical Biology and Medicine. 12:409-415 |
| ISSN: | 0891-5849 |
| DOI: | 10.1016/0891-5849(92)90090-4 |
| Popis: | A skin burn is a common traumatic injury that results in both local tissue damage and a systematic mediater-induced response. There is evidence of both local and sysemic oxidant changes manifsted by lipid peroxidation in animal burn models and also in burned man. Both increased xanthine oxidase and neutrophil activation appear to be the oxidant sources. Animal studies have also demonstrated decreased burn edema, and also decreased distant organ dysfunction with the use of antioxidants, suggesting a cause-and-effect relationship, which needs to be tested in man. Smoke inhalation injury, a chemical injury to the airways caused incomplete products of combustion, is frequently seen in conjuction with a body burn. Lipid peroxidation, both in lung and in distant organs, is also seen with this injury. The combined body burn and smoke inhalation injury lead to a marked increase in mortality rate and also an increase in the degree of generalized oxidant release and lipid peroxidation. Although data in man are limited, the available information, along with that from animal research on burns and smoke inhalation, indicates oxidants may well play a key role, and antioxidants may be of clinical therapeutic use. |
| Databáze: | OpenAIRE |
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