Thallium-201 brain SPECT to diagnose aggressiveness of meningiomas
| Autor: | Masahiro Ohashi, Koji Nobata, Sohtaro Sakai, Kenji Yamamoto, Shintaro Terahata, Kiyoshi Kakuda, Suzuka Taki, Keiko Kinuya, Seigo Kinuya, Syotaro Itoh |
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| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty Malignant meningioma chemistry.chemical_element Single-photon emission computed tomography Sensitivity and Specificity Lesion Meningioma Meningeal Neoplasms medicine Humans Neoplasm Invasiveness Radiology Nuclear Medicine and imaging Thallium Neoplasm Staging Tomography Emission-Computed Single-Photon medicine.diagnostic_test Brain Neoplasms business.industry Meninges Reproducibility of Results Histology General Medicine Middle Aged medicine.disease Skull medicine.anatomical_structure chemistry Feasibility Studies Radiopharmaceuticals medicine.symptom business |
| Zdroj: | Annals of Nuclear Medicine. 17:463-467 |
| ISSN: | 1864-6433 0914-7187 |
| DOI: | 10.1007/bf03006435 |
| Popis: | This investigation was conducted to determine the ability of 201Tl brain SPECT with respect to preoperative prediction of lesional aggressiveness of meningioma. Fifty-nine lesions in 42 patients were examined. Early (15 min) and late (3 h) SPECT were obtained. Early uptake ratio (ER; lesion to normal brain average count ratio), late uptake ratio (LR) and the ratio of LR to ER (L/E ratio) were calculated. Twenty-three lesions exhibited malignant features based on histologic or clinical course such as recurrence or skull invasion. Both ER and LR of malignant meningiomas were significantly higher than those in thirty-six benign lesions. Benign lesions were classified into two groups for further analysis: meningotheliomatous type, which is the most common histology, and benign lesions other than the meningotheliomatous (other benign) type. ER in other benign type was lower than the meningotheliomatous and the malignant type. LR afforded differentiation of the malignant type from the two benign types. These two benign types could be distinguished on the basis of the L/E ratio. These results indicate that high pre-operative ER and LR values in patients with meningioma are indicators of the aggressiveness of lesions, i.e., malignant meningioma, recurrence or skull invasion. |
| Databáze: | OpenAIRE |
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