Tight Junction Proteins and Oxidative Stress in Heavy Metals-Induced Nephrotoxicity
| Autor: | Eduardo Molina-Jijón, Pablo Bautista-García, Yazmin Debray-García, José L. Reyes, Rafael Rodríguez-Muñoz, María del Carmen Namorado |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Kidney Glomerulus lcsh:Medicine Tretinoin Review Article Nephron Oxidative phosphorylation Kidney medicine.disease_cause Antioxidants General Biochemistry Genetics and Molecular Biology Nephrotoxicity Kidney Tubules Proximal Metals Heavy Internal medicine medicine Humans Tight Junction Proteins General Immunology and Microbiology Tight junction urogenital system Chemistry lcsh:R Acute kidney injury Nephrons General Medicine Anatomy Acute Kidney Injury medicine.disease Oxidative Stress medicine.anatomical_structure Endocrinology Oxidative stress |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2013 (2013) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Kidney is a target organ for heavy metals. They accumulate in several segments of the nephron and cause profound alterations in morphology and function. Acute intoxication frequently causes acute renal failure. The effects of chronic exposure have not been fully disclosed. In recent years increasing awareness of the consequences of their presence in the kidney has evolved. In this review we focus on the alterations induced by heavy metals on the intercellular junctions of the kidney. We describe that in addition to the proximal tubule, which has been recognized as the main site of accumulation and injury, other segments of the nephron, such as glomeruli, vessels, and distal nephron, show also deleterious effects. We also emphasize the participation of oxidative stress as a relevant component of the renal damage induced by heavy metals and the beneficial effect that some antioxidant drugs, such as vitamin A (all-trans-retinoic acid) and vitamin E (α-tocopherol), depict on the morphological and functional alterations induced by heavy metals. |
| Databáze: | OpenAIRE |
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