Facial Nerve Repair by Muscle-Vein Conduit in Rats: Functional Recovery and Muscle Reinnervation
| Autor: | Dilyana Gencheva, Nektarios Sinis, Doychin N. Angelov, Svenja Rink, Levent Sarikcioglu, Diana S.Y. Abdulla, Theodora Papamitsou, Maria Eleni Manthou, Habib Bendella |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_treatment
0206 medical engineering Biomedical Engineering Bioengineering 02 engineering and technology Biochemistry Biomaterials 03 medical and health sciences Electrical conduit Medicine Animals Vein Head and neck Muscle Skeletal 030304 developmental biology Facial Nerve Injuries 0303 health sciences business.industry Muscles Motor end plates Anatomy Recovery of Function Functional recovery 020601 biomedical engineering Facial nerve Nerve Regeneration Rats Facial Nerve medicine.anatomical_structure Axotomy business Reinnervation |
| Zdroj: | Tissue engineering. Part A. 27(5-6) |
| ISSN: | 1937-335X |
| Popis: | The facial nerve is the most frequently damaged nerve in head and neck traumata. Repair of interrupted nerves is generally reinforced by fine microsurgical techniques; nevertheless, regaining all functions is the exception rather than the rule. The so-called "postparalytic syndrome," which includes synkinesia and altered blink reflexes, follows nerve injury. The purpose of this study was to examine if nerve-gap repair using an autologous vein filled with skeletal muscle would improve axonal regeneration, reduce neuromuscular junction polyinnervation, and improve the recovery of whisking in rats with transected and sutured right buccal branches of the facial nerve. Vibrissal motor performance was studied with the use of a video motion analysis. Immunofluorescence was used to visualize and analyze target muscle reinnervation. The results taken together indicate a positive effect of muscle-vein-combined conduit (MVCC) on the improvement of the whisking function after reparation of the facial nerve in rats. The findings support the recent suggestion that a venal graft with implantation of a trophic source, such as autologous denervated skeletal muscle, may promote the monoinnervation degree and ameliorate coordinated function of the corresponding muscles. |
| Databáze: | OpenAIRE |
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