Prevalence, clinical characteristics and outcomes of Guillain-Barré syndrome spectrum associated with COVID-19: A systematic review and meta-analysis
| Autor: | Paraskevi C. Fragkou, Panagiotis Kokotis, Georgios Tsivgoulis, Christos Moschovos, Maria-Ioanna Stefanou, Androniki Naska, Lina Palaiodimou, Christos Bakirtzis, Elisabeth Chroni, Ioannis Michopoulos, Aristeidis H. Katsanos, Sotirios Tsiodras, Theodoros I Vassilakopoulos, Marianna Papadopoulou |
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| Rok vydání: | 2021 |
| Předmět: |
Guillain−Barré syndrome
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) prevalence Review Article Guillain-Barre Syndrome 03 medical and health sciences 0302 clinical medicine COVID‐19 acute inflammatory demyelinating polyneuropathy Internal medicine medicine Humans 030212 general & internal medicine Hospital Mortality Review Articles Guillain-Barre syndrome business.industry SARS-CoV-2 COVID-19 Odds ratio medicine.disease mortality Confidence interval Neurology Meta-analysis Concomitant Cohort Observational study Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Neurology |
| ISSN: | 1468-1331 |
| Popis: | Background and purpose Mounting evidence supports an association between Guillain−Barré syndrome spectrum (GBSs) and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. However, GBSs in the setting of coronavirus disease 2019 (COVID‐19) remains poorly characterized, whilst GBSs prevalence amongst COVID‐19 patients has not been previously systematically evaluated using a meta‐analytical approach. Methods A systematic review and meta‐analysis of observational cohort and case series studies reporting on the occurrence, clinical characteristics and outcomes of patients with COVID‐19‐associated GBSs was performed. A random‐effects model was used to calculate pooled estimates and odds ratios (ORs) with corresponding 95% confidence intervals (CIs), compared to non‐COVID‐19, contemporary or historical GBSs patients. Results Eighteen eligible studies (11 cohorts, seven case series) were identified including a total of 136,746 COVID‐19 patients. Amongst COVID‐19 patients, including hospitalized and non‐hospitalized cases, the pooled GBSs prevalence was 0.15‰ (95% CI 0%–0.49‰; I 2 = 96%). Compared with non‐infected contemporary or historical controls, patients with SARS‐CoV‐2 infection had increased odds for demyelinating GBSs subtypes (OR 3.27, 95% CI 1.32%–8.09%; I 2 = 0%). In SARS‐CoV‐2‐infected patients, olfactory or concomitant cranial nerve involvement was noted in 41.4% (95% CI 3.5%–60.4%; I 2 = 46%) and 42.8% (95% CI 32.8%–53%; I 2 = 0%) of the patients, respectively. Clinical outcomes including in‐hospital mortality were comparable between COVID‐19 GBSs patients and non‐infected contemporary or historical GBSs controls. Conclusion GBSs prevalence was estimated at 15 cases per 100,000 SARS‐CoV‐2 infections. COVID‐19 appears to be associated with an increased likelihood of GBSs and with demyelinating GBSs variants in particular. |
| Databáze: | OpenAIRE |
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