Post-mortem dissection of COVID-19: a pathogenic role for macrophages?
| Autor: | Prasad Palani Velu, Christopher D. Lucas, Andrew Conway Morris |
|---|---|
| Přispěvatelé: | Velu, Prasad P [0000-0003-1766-202X], Lucas, Christopher D [0000-0002-7523-0295], Conway Morris, Andrew [0000-0002-3211-3216], Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: |
Understanding the Disease
0303 health sciences medicine.medical_specialty 2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) Clinician scientist business.industry SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) General surgery Dissection Macrophages education COVID-19 Critical Care and Intensive Care Medicine 3. Good health 03 medical and health sciences 0302 clinical medicine 030228 respiratory system medicine Humans Autopsy business health care economics and organizations 030304 developmental biology |
| Zdroj: | Velu, P P, Lucas, C D & Conway Morris, A 2021, ' Post-mortem dissection of COVID-19: a pathogenic role for macrophages? ', Intensive Care Medicine . https://doi.org/10.1007/s00134-021-06509-9 Intensive Care Medicine |
| DOI: | 10.1007/s00134-021-06509-9 |
| Popis: | Acute respiratory failure is the leading cause of death in severe COVID-19. By combining rapid tissue sampling at autopsy with high dimensional analyses, including measurement of immune cells, proteins and RNA, unparalleled insights into the mechanisms of dysregulated inflammation in COVID-19 have been obtained1–4. Here we summarise some of the conceptual advances revealed by post-mortem studies of severe COVID-19, and make particular reference to the apparent dominance of macrophages, how this may relate to disease pathophysiology, and the opportunities for targeted therapeutic intervention. |
| Databáze: | OpenAIRE |
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