Purinergic system ecto-enzymes participate in the thromboregulation of patients with indeterminate form of Chagas disease

Autor: Viviane do Carmo Gonçalves Souza, Daniela B.R. Leal, Maria Rosa Chitolina Schetinger, Cristiano Bicca Noal, Maria Beatriz Moretto, Juliana Fleck, Luiz Felipe Dias Carli, Karine Bizzi Schlemmer, Jeandre Augusto dos Santos Jaques, Victor C. Pimentel, Claudio A.M. Leal, Margarete Dulce Bagatini
Rok vydání: 2012
Předmět:
Zdroj: Purinergic Signalling. 8:753-762
ISSN: 1573-9546
1573-9538
DOI: 10.1007/s11302-012-9322-7
Popis: Chagas disease (CD) is a chronic and endemic illness caused by the parasite Trypanosoma cruzi. Microvascular disturbances play an important role in the progress of the disease. The purinergic signaling system participates in regulatory functions, such as immunomodulation, neuroprotection, and thromboregulation. This study aimed to investigate the activities of purinergic system ecto-enzymes present on the platelet surface and the platelet aggregation profile from patients with indeterminate form of Chagas disease (IFCD). Thirty patients diagnosed with IFCD and 30 healthy subjects were selected. Ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase), ecto-nucleotide pyrophosphatase/phosphodiesterase (E-NPP), ecto-5′-nucleotidase (E-5′-NT) and ecto-adenosine deaminase (E-ADA) activities were measured in platelets isolated from these individuals as well as the platelet aggregation. Results demonstrated an increase of 21 % in the E-NPP activity and 30 % in the E-5′-NT activity in IFCD group (P
Databáze: OpenAIRE
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