Diagnostic value and prognostic significance of LI‑cadherin and miR‑378e in colorectal cancer

Autor:	Weiwei Xu, Jixin Fu, Xujie Wang, Zongxian Li, Zhihua Li
Rok vydání:	2020
Předmět:	Cancer Research medicine.medical_specialty Lymphatic metastasis Oncogene Receiver operating characteristic medicine.diagnostic_test Colorectal cancer business.industry colorectal cancer LI-cadherin Physical examination Articles Cell cycle medicine.disease Molecular medicine Gastroenterology miR-378e LI-CADHERIN Oncology Internal medicine medicine diagnostic value prognosis business
Zdroj:	Oncology Letters
ISSN:	1792-1082 1792-1074
DOI:	10.3892/ol.2020.11755
Popis:	Expression levels of LI-cadherin and miR-378e in the serum of patients with colorectal cancer, and the diagnostic value and prognostic significance in colorectal cancer were investigated. A total of 110 patients who were diagnosed with colorectal cancer in Weihai Central Hospital, from January 2012 to November 2014, were selected and enrolled in the experimental group, and 90 healthy subjects who underwent physical examination were enrolled in the control group. The expression level of miR-378e in serum was detected by reverse transcription-quantitative PCR and the expression of LI-cadherin in serum was detected by ELISA. ROC curves of LI-cadherin and miR-378e were drawn and the sensitivity and specificity of the diagnosis were estimated. The association of the expression levels of LI-cadherin and miR-378e with the survival of the patients was analyzed. LI-cadherin and miR-378e expression levels were significantly higher in the control group than those in the experimental group (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ede1718727c6704963e9538d715ad2 https://doi.org/10.3892/ol.2020.11755 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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