Histone H2A variant synthesis in aging human diploid cells

Autor:	Robert T. Dell'Orco, Maria I. Worthington
Rok vydání:	1991
Předmět:	Senescence Aging Time Factors biology Cytological Techniques G1 Phase Cell cycle Fibroblasts Diploidy Resting Phase Cell Cycle WI-38 In vitro Cell biology S Phase Histones Histone Biochemistry Cell culture Histone H2A biology.protein Humans Ploidy
Zdroj:	Journal of gerontology. 46(2)
ISSN:	0022-1422
Popis:	The synthesis of the various classes of core particle histones was determined in human diploid fibroblast-like cells of different in vitro ages as they were stimulated to enter the cell cycle. Histone H2A synthesis in older populations was lower during G1 but was similar to younger cells at G0/G1 and S phases. The reduced synthesis during G1 was primarily the result of a decline in the synthesis of the H2A.1/.2 component.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ebad087ce2d9e1a0cb4f98b909dcf8 https://pubmed.ncbi.nlm.nih.gov/1997569 Zobrazit plný text záznamu