Enantioselective metabolism of the designer drugs 3,4-methylenedioxymethamphetamine (‘ecstasy’) and 3,4-methylenedioxyethylamphetamine (‘eve’) isomers in rat brain and blood
| Autor: | Karl-Artur Kovar, Andreas Mayerhofer, Anja Meyer, Werner J. Schmidt |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.drug_class
Injections Subcutaneous N-Methyl-3 4-methylenedioxyamphetamine Ecstasy Striatum Pharmacology Gas Chromatography-Mass Spectrometry Designer Drugs Rats Sprague-Dawley Serotonin Agents Isomerism mental disorders medicine Animals Chromatography High Pressure Liquid Whole blood Brain Chemistry Cerebral Cortex Analysis of Variance Chemistry General Neuroscience Brain MDMA Metabolism Rat brain Corpus Striatum Rats Designer drug Hallucinogens psychological phenomena and processes medicine.drug |
| Zdroj: | Neuroscience Letters. 330:193-197 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/s0304-3940(02)00776-0 |
| Popis: | The metabolism of MDA (3,4-methylenedioxyamphetamine), HMMA (3-hydroxy-4-methoxymethylamphetamine) and HME (3-hydroxy-4-methoxyethylamphetamin) of the popular designer drugs MDMA (‘ecstasy’, 3,4-methylenedioxymethamphetamine) and MDE (‘eve’, 3,4-methylenedioxyethylamphetamine) was determined in rat serum, whole blood and urine, as well as in whole brain structures (cortex and striatum) after subcutaneous administration of 20 mg/kg MDMA and MDE, respectively. MDMA and MDE were extracted from serum and homogenized brain structures using a solid-phase extraction procedure. The extracts were examined by a validated high-performance liquid chromatography procedure coupled with fluorimetric detection. Our results demonstrate that MDMA is metabolized to a higher degree than MDE, resulting in a higher concentration of neurotoxic dihydroxymetabolites and (S)-MDA. There was no difference between the metabolism of MDMA and MDE and its respective isomers. Different concentrations of the respective isomers of MDMA and MDE let us suggest an enantioselective metabolism for both MDMA and MDE. |
| Databáze: | OpenAIRE |
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