Alterations in Cortical Morphology after Neonatal Stroke: Compensation in the Contralesional Hemisphere?

Autor: Mickael Dinomais, Julien Lefèvre, Mariam Al Harrach, Lucie Hertz-Pannier, Samuel Groeschel, François Rousseau, Amine Bohi, Xiaoyu Wang, Stéphane Chabrier
Přispěvatelé: Laboratoire Angevin de Recherche en Ingénierie des Systèmes (LARIS), Université d'Angers (UA), Département lmage et Traitement Information (IMT Atlantique - ITI), IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire de Traitement de l'Information Medicale (LaTIM), Institut National de la Santé et de la Recherche Médicale (INSERM)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Unité de recherche en NeuroImagerie Applicative Clinique et Translationnelle (UNIACT), Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, INSERM U1059, SAINBIOSE - Santé, Ingénierie, Biologie, Saint-Etienne (SAINBIOSE-ENSMSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), IMT Atlantique (IMT Atlantique), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut Brestois Santé Agro Matière (IBSAM), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Rousseau, François, Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Brain development
Cortical morphology
[SCCO.COMP]Cognitive science/Computer science
Biology
Lateralization of brain function
Cohort Studies
Lesion
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Developmental Neuroscience
Image Processing
Computer-Assisted
medicine
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging
Humans
Child
Gyrification
Neonatal stroke
ComputingMilieux_MISCELLANEOUS
[SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing
Cerebral Cortex
[SDV.IB] Life Sciences [q-bio]/Bioengineering
Neuronal Plasticity
[SCCO.NEUR]Cognitive science/Neuroscience
Brain morphometry
Infant
Newborn
[INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV]
[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph]
Organ Size
Anatomy
medicine.disease
Magnetic Resonance Imaging
[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation
Stroke
030104 developmental biology
[INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV]
Female
[SDV.IB]Life Sciences [q-bio]/Bioengineering
medicine.symptom
Occipital lobe
[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
030217 neurology & neurosurgery
Zdroj: Developmental Neurobiology
Developmental Neurobiology, Wiley, 2019, 79 (4), pp.303-316. ⟨10.1002/dneu.22679⟩
Developmental Neurobiology, 2019, 79 (4), pp.303-316. ⟨10.1002/dneu.22679⟩
ISSN: 1932-8451
1932-846X
DOI: 10.1002/dneu.22679⟩
Popis: Although neonatal arterial ischemic stroke is now well-studied, its complex consequences on long-term cortical brain development has not yet been solved. In order to understand the brain development after focal early brain lesion, brain morphometry needs to be evaluated using structural parameters. In this work, our aim was to study and analyze the changes in morphometry of ipsi- and contralesional hemispheres in seven-year-old children following neonatal stroke. Therefore, we used surface-based morphometry in order to examine the cortical thickness, surface area, cortical volume, and local gyrification index in two groups of children that suffered from neonatal stroke in the left (n = 19) and right hemispheres (n = 15) and a group of healthy controls (n = 30). Reduced cortical thickness, surface area, and cortical volumes were observed in the ipsilesional hemispheres for both groups in comparison with controls. For the group with left-sided lesions, higher gyrification of the contralesional hemisphere was observed primarily in the occipital region along with higher surface area and cortical volume. As for the group with right-sided lesions, higher gyrification was detected in two separate clusters also in the occipital lobe of the contralesional hemisphere, without a significant change in cortical thickness, surface area, or cortical volume. This is the first time that alterations of structural parameters are detected in the "healthy" hemisphere after unilateral neonatal stroke indicative of a compensatory phenomenon. Moreover, findings presented in this work suggest that lesion lateralization might have an influence on brain development and maturation.
Databáze: OpenAIRE
Externí odkaz: