Association between Concomitant Use of Acyclovir or Valacyclovir with NSAIDs and an Increased Risk of Acute Kidney Injury: Data Mining of FDA Adverse Event Reporting System
| Autor: | Huiyi Li, Haona Li, Jinhai Shi, Zhihua Yue |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Risk medicine.medical_specialty 030106 microbiology Pharmaceutical Science Acyclovir Pharmacology urologic and male genital diseases Piroxicam Kidney Antiviral Agents 03 medical and health sciences Adverse Event Reporting System 0302 clinical medicine Diclofenac Japan Internal medicine medicine Adverse Drug Reaction Reporting Systems Data Mining Humans Drug Interactions Prodrugs 030212 general & internal medicine Adverse effect Aged Chi-Square Distribution business.industry United States Food and Drug Administration Anti-Inflammatory Agents Non-Steroidal Acute kidney injury virus diseases Valine General Medicine Loxoprofen Acute Kidney Injury Middle Aged medicine.disease United States Ketorolac Concomitant Valacyclovir Female business medicine.drug |
| Zdroj: | Biologicalpharmaceutical bulletin. 41(2) |
| ISSN: | 1347-5215 |
| Popis: | Nonsteroidal anti-inflammatory drugs (NSAIDs) are likely to be used concomitantly with acyclovir or valacyclovir in clinical practice, but the study on the safety of such combinations was seldom reported. The objective of the study was to investigate reports of acute kidney injury (AKI) events associated with the concomitant use of oral acyclovir or valacyclovir with an NSAID by using the United States Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) database between January 2004 and June 2012. The frequency of AKI events in patients while simultaneously taking either acyclovir or valacyclovir and an NSAID was compared using the Chi-square test. The effect of concomitant use of acyclovir or valacyclovir and individual NSAIDs on AKI was analyzed by the reporting odds ratio (ROR). The results showed that AKI was reported as the adverse event in 8.6% of the 10923 patients taking valacyclovir compared with 8.7% of the 2556 patients taking acyclovir (p=NS). However, AKI was significantly more frequently reported in patients simultaneously taking valacyclovir and an NSAID (19.4%) than in patients simultaneously taking acyclovir and an NSAID (10.5%) (p |
| Databáze: | OpenAIRE |
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