Cerebral Hemodynamic and Ventilatory Responses to Hypoxia, Hypercapnia, and Hypocapnia during 5 Days at 4,350 m
| Autor: | Stéphane Perrey, Patrick Levy, Thomas Rupp, Pierre Bouzat, Carsten Lundby, Paul Robach, François Estève, Samuel Verges |
|---|---|
| Přispěvatelé: | Serduc, Raphael, Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), INSERM U836, équipe 6, Rayonnement synchrotron et recherche médicale, Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neuro-imagerie fonctionnelle et métabolique (ANTE-INSERM U836, équipe 5), Institute of physiology, Universität Zürich [Zürich] = University of Zurich (UZH), Euromov (EuroMov), Université de Montpellier (UM), HP2 Laboratory, Université Joseph Fourier - Grenoble 1 (UJF), Ecole nationale de ski et d'alpinisme, Hypoxie et physiopathologies cardiovasculaire et respiratoire, Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2013 |
| Předmět: |
Male
Middle Cerebral Artery Ultrasonography Doppler Transcranial MESH: Anoxia Hemodynamics 030204 cardiovascular system & hematology MESH: Spectroscopy Near-Infrared Hypercapnia Hemoglobins 0302 clinical medicine Hypocapnia Surveys and Questionnaires MESH: Oxygen Consumption Hypoxia Spectroscopy Near-Infrared Altitude Brain MESH: Ultrasonography Doppler Transcranial MESH: Cerebrovascular Circulation MESH: Hemoglobins Neurology Cerebrovascular Circulation Anesthesia Middle cerebral artery Original Article [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] medicine.symptom Cardiology and Cardiovascular Medicine Adult MESH: Hypocapnia MESH: Brain 03 medical and health sciences Oxygen Consumption medicine.artery medicine Humans [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] MESH: Humans business.industry MESH: Questionnaires MESH: Adult Oxygenation MESH: Middle Cerebral Artery Hypoxia (medical) MESH: Altitude medicine.disease MESH: Male Transcranial Doppler Cerebral hemodynamics MESH: Hypercapnia Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Cerebral Blood Flow and Metabolism Journal of Cerebral Blood Flow and Metabolism, 2014, 34 (1), pp.52-60. ⟨10.1038/jcbfm.2013.167⟩ Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2014, 34 (1), pp.52-60. ⟨10.1038/jcbfm.2013.167⟩ |
| ISSN: | 1559-7016 0271-678X |
| DOI: | 10.1038/jcbfm.2013.167 |
| Popis: | This study investigated the changes in cerebral near-infrared spectroscopy (NIRS) signals, cerebrovascular and ventilatory responses to hypoxia and CO2 during altitude exposure. At sea level (SL), after 24 hours and 5 days at 4,350 m, 11 healthy subjects were exposed to normoxia, isocapnic hypoxia, hypercapnia, and hypocapnia. The following parameters were measured: prefrontal tissue oxygenation index (TOI), oxy- (HbO2), deoxy- and total hemoglobin (HbTot) concentrations with NIRS, blood velocity in the middle cerebral artery (MCAv) with transcranial Doppler and ventilation. Smaller prefrontal deoxygenation and larger ΔHbTot in response to hypoxia were observed at altitude compared with SL (day 5: ΔHbO2−0.6±1.1 versus −1.8±1.3 μmol/cmper mm Hg and ΔHbTot 1.4±1.3 versus 0.7±1.1 μmol/cm per mm Hg). The hypoxic MCAv and ventilatory responses were enhanced at altitude. Prefrontal oxygenation increased less in response to hypercapnia at altitude compared with SL (day 5: ΔTOI 0.3±0.2 versus 0.5±0.3% mm Hg). The hypercapnic MCAv and ventilatory responses were decreased and increased, respectively, at altitude. Hemodynamic responses to hypocapnia did not change at altitude. Short-term altitude exposure improves cerebral oxygenation in response to hypoxia but decreases it during hypercapnia. Although these changes may be relevant for conditions such as exercise or sleep at altitude, they were not associated with symptoms of acute mountain sickness. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|