Preventive effects of curcumin on different aspiration material-induced lung injury in rats
| Autor: | Burhan Aksu, Aygul Guzel, Serap Karasalihoğlu, Umit Nusret Basaran, Hafise Uzun, Dildar Konukoglu, Ahmet Güzel, Mehmet Kanter, Omer Yalcin |
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| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty Curcumin Necrosis Acute Lung Injury Lung injury Pharmacology Rats Sprague-Dawley Random Allocation chemistry.chemical_compound Hydroxyproline Malondialdehyde medicine Animals Enzyme Inhibitors Lung chemistry.chemical_classification Glutathione Peroxidase biology Superoxide Dismutase business.industry Glutathione peroxidase Respiratory Aspiration General Medicine medicine.disease Immunohistochemistry Rats Nitric oxide synthase Pulmonary aspiration chemistry Pediatrics Perinatology and Child Health biology.protein Surgery medicine.symptom business |
| Zdroj: | Pediatric Surgery International. 25:83-92 |
| ISSN: | 1437-9813 0179-0358 |
| DOI: | 10.1007/s00383-008-2282-x |
| Popis: | We have studied whether curcumin protects different pulmonary aspiration material-induced lung injury in rats. The experiments were designed in 60 Sprague–Dawley rats, randomly allotted into one of six groups (n = 10): normal saline (NS, control), enteral formula (Biosorb Energy Plus, BIO), hydrochloric acid (HCl), NS + curcumin-treated, BIO + curcumin-treated, and HCl + curcumin-treated. NS, BIO, HCl were injected in to the lungs. The rats received curcumin twice daily only for 7 days. Seven days later, both lungs in all groups were examined histopathologically, immunohistochemically, and biochemically. Histopathologic examination was performed according to the presence of peribronchial inflammatory cell infiltration, alveolar septal infiltration, alveolar edema, alveolar exudate, alveolar histiocytes, interstitial fibrosis, granuloma, and necrosis formation. Immunohistochemical assessments were examined for the activity of inducible nitric oxide synthase (iNOS) and the expression of surfactant protein D (SP-D). Malondialdehyde (MDA), hydroxyproline (HP), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activity were measured in the lung tissue. Our findings show that curcumin inhibits the inflammatory response reducing significantly (P |
| Databáze: | OpenAIRE |
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