Prognostic Value of TP53 Codon 72 Polymorphism in Advanced Gastric Adenocarcinoma
| Autor: | Zun-Wu Zhang, Derek Alderson, Jeffrey M P Holly, Roger Feakins, Michael J.G. Farthing, Nicola J. Laurence, Andrew Hollowood, Jyoti Gupta, P.V. Newcomb, Moganaden Moorghen |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Genotype Tumor suppressor gene Adenocarcinoma Biology Arginine Polymerase Chain Reaction Gastroenterology Age Distribution Risk Factors Stomach Neoplasms Internal medicine medicine Humans Genetic Predisposition to Disease Allele Codon Survival rate Aged Neoplasm Staging Aged 80 and over Polymorphism Genetic Stomach Cancer DNA Neoplasm Odds ratio Middle Aged Genes p53 Prognosis medicine.disease Survival Rate Endocrinology medicine.anatomical_structure Oncology Female |
| Zdroj: | Clinical Cancer Research. 10:131-135 |
| ISSN: | 1557-3265 1078-0432 |
| DOI: | 10.1158/1078-0432.ccr-0853-3 |
| Popis: | Purpose: A common polymorphism of the tumor suppressor gene TP53 at codon 72 has been associated with human cancer susceptibility. The prognostic role of the polymorphism was assessed in 102 patients with advanced gastric adenocarcinoma. Experimental Design: We followed up 102 consecutive Caucasian patients with advanced gastric adenocarcinoma for >5 years and determined the status of the TP53 codon 72 polymorphism in DNA samples extracted from archived gastric tissues. Results: The frequency of the arginine homozygous allele was positively correlated to patient age at baseline (P = 0.002). However, the age-related increase in the percentage of codon 72 arginine p53 was not correlated to the prognosis for gastric cancer patients. Multivariable analysis in patients who had surgery showed that baseline age may be inversely associated with patient survival (odds ratio, 1.1; 95% confidence interval, 1.0–1.2; P = 0.02). Furthermore, alcohol consumption may be associated with reduced survival (P = 0.06). Conclusions: These findings indicate that codon 72 arginine p53 may not be associated with a prolonged survival in patients with advanced gastric adenocarcinoma, but further study is needed to assess whether this polymorphism is associated with a late onset or slow progress of early gastric adenocarcinoma. |
| Databáze: | OpenAIRE |
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