How to structure an oncogenetics service for the public health system: Report of the implementation of the first service in Northeastern Brazil
| Autor: | Flávio da Silveira Bitencourt, Paulo Goberlânio de Barros Silva, Clarissa Gondim Picanço de Albuquerque, Marcos Venício Alves Lima, Deysi Viviana Tenazoa Wong, Francisca Fernanda Barbosa Oliveira, Isabelle Joyce de Lima Silva-Fernandes, Camila Sampaio Nogueira |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Referral Biology Specimen Handling 03 medical and health sciences 0302 clinical medicine Neoplasms Genetics medicine Humans Genetic Predisposition to Disease Genetic Testing Molecular Biology Genetic testing Service (business) Cancer prevention medicine.diagnostic_test Public health Oncogenes medicine.disease Lynch syndrome Disadvantaged 030220 oncology & carcinogenesis Family medicine Mutation Public Health Administration PDCA Brazil |
| Zdroj: | Cancer Genetics. :6-11 |
| ISSN: | 2210-7762 |
| Popis: | Introduction Identifying carriers of genetic mutations that increase the risk of developing cancer allows to adopt timely risk-reducing strategies. However, due to the elevated cost of genetic testing, few oncogenetics services are available in the Brazilian public health care system, especially in economically disadvantaged areas. Objective To describe the implementation of an oncogenetics service for patients suspected of hereditary cancer syndromes (HBOC and HNPCC) at a philanthropic referral oncology hospital in Northeastern Brazil, funded by the Ministry of Health's National Oncology Care Support Program (PRONON). Methods The service was implemented with the PDCA method (Plan, Do, Check and Act). Results During the first year of operation (starting in August 2018), 675 individuals were examined, of whom 272 patients and 98 family members were submitted to genetic testing. This included the collection of 338 DNA samples of which 300 were sequenced. The analysis identified 48 (17.1%) mutations for HBOC and 19 (6.8%) for HNPCC. Conclusion In one year, the oncogenetics service was able to benefit over 300 families by generating advanced molecular data which may be used for tailoring cancer prevention and management. |
| Databáze: | OpenAIRE |
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