Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors
| Autor: | Ronit Sarid, Giuseppe Torelli, Dana G. Wolf, Mario Luppi, Barbara Crescenzi, Luisa Ravazzini, Cristina Mecucci, Fabio Facchetti, Milena Alù, Valeria Rasini, Elisa Rossi, Silvana Festa, Thomas F. Schulz, Patrizia Barozzi |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty viruses Antigens CD34 Biology Immunofluorescence General Biochemistry Genetics and Molecular Biology Antigen post-transplant kaposi sarcoma HHV-8 progenitors medicine Humans Donor derived Progenitor cell Antigens Viral Sarcoma Kaposi Kidney transplantation Sex Chromosomes medicine.diagnostic_test HLA-A Antigens virus diseases Nuclear Proteins General Medicine HLA-DR Antigens medicine.disease Immunohistochemistry Kidney Transplantation Post transplant Tissue Donors Herpesvirus 8 Human Neoplastic Stem Cells Sarcoma |
| Zdroj: | Nature medicine. 9(5) |
| ISSN: | 1078-8956 |
| Popis: | Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS- associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS. |
| Databáze: | OpenAIRE |
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