Oxidative stress during recovery from muscle atrophy
| Autor: | Junko Kodama, Yoshinori Itokawa, Takako Kishibe, Hisao Kondo |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Lipid peroxidation Biophysics medicine.disease_cause Biochemistry Immobilization chemistry.chemical_compound Atrophy Recovery Structural Biology Internal medicine Genetics medicine TBARS Animals Vitamin E Rats Wistar Molecular Biology Muscles Organ Size Cell Biology Glutathione Thiobarbiturates medicine.disease Muscle atrophy Rats Muscular Atrophy Endocrinology medicine.anatomical_structure chemistry Oxidative stress Ankle medicine.symptom Oxidation-Reduction |
| Zdroj: | FEBS Letters. 326:189-191 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(93)81788-2 |
| Popis: | Single ankle joints of male Wistar rats (15-week-old) were immobilized in the extended position for 7 days and remobilized for 5 days after the immobilization period. Atrophic and contralateral soleus, typical slow red muscles, were collected and their levels of thiobarbituric acid-reactive substance (TBARS) and glutathione were measured. Five-day remobilization did not increase muscle weight significantly. However, there were significant increases in TBARS and oxidized glutathione in the recovering muscle, which strongly suggested that enhanced oxidative stress occurred during the recovery from disuse muscle atrophy. Vitamin E injection accelerated the recovery from atrophy, thus showing that oxidative stress slowed it down. |
| Databáze: | OpenAIRE |
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