Increased Platelet Adhesiveness as a Familial Characteristic
| Autor: | Aileen Burn, M. C. G. Israëls, C. G. Geary, A. G. Papayannis |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
Time Factors Hemorrhage Disease Hematocrit Hemorrhagic Disorders Hemorrhagic disorder Platelet Adhesiveness Von willebrand Platelet adhesiveness Von Willebrand disease Humans Medicine Genes Dominant Blood Platelet Disorders Factor VIII medicine.diagnostic_test business.industry Hematology medicine.disease Blood Cell Count von Willebrand Diseases Immunology Female Abnormality business |
| Zdroj: | British Journal of Haematology. 24:435-441 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/j.1365-2141.1973.tb01669.x |
| Popis: | Summary. Two families are described in which many members were shown to have increased platclet adhesiveness, using a modification of the Salzman techniquc. The abnormality appears to be inherited as an autosomal dominant characteristic. In addition, one member of each family had an abnormally low level of plasma factor VIII (AHG) and a moderatcly severe haemorrhagic disorder, while two members of one of the families had factor-VIII levels at the lower limit of normal. Several individuals showed a mild haemorrhagic disorder, but none had thrombotic manifestations. The significance of these findings and their distinction from those present in von Willebrand's disease is discussed. |
| Databáze: | OpenAIRE |
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