A phase I/IIa clinical trial in stage IV melanoma of an autologous tumor–dendritic cell fusion (dendritoma) vaccine with low dose interleukin-2
| Autor: | Madeline Flores, Garth S. Herbert, Jonathan Martin, Diane F. Hale, Xianzhong Yu, George E. Peoples, Mark O. Hardin, Julia M. Greene, Doreen O. Jackson, Timothy J. Vreeland, Erika J Schneble, Thomas E. Wagner |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Interleukin 2 Cancer Research medicine.medical_specialty medicine.medical_treatment Immunology Kaplan-Meier Estimate Cancer Vaccines Gastroenterology Drug Administration Schedule 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Immunology and Allergy Stage (cooking) Melanoma Aged Neoplasm Staging Dose-Response Relationship Drug business.industry Nausea Dendritic Cells Immunotherapy Middle Aged medicine.disease Arthralgia Combined Modality Therapy Chills Surgery Clinical trial Treatment Outcome 030104 developmental biology Cytokine Oncology Erythema 030220 oncology & carcinogenesis Toxicity Interleukin-2 Female Neoplasm Recurrence Local business Adjuvant medicine.drug |
| Zdroj: | Cancer Immunology, Immunotherapy. 65:383-392 |
| ISSN: | 1432-0851 0340-7004 |
| Popis: | Stage IV melanoma has high mortality, largely unaffected by traditional therapies. Immunotherapy including cytokine therapies and checkpoint inhibitors improves outcomes, but has significant toxicities. In this phase I/IIa trial, we investigated safety and efficacy of a dendritoma vaccine, an active, specific immunotherapy, in stage IV melanoma patients. Autologous tumor lysate and dendritic cells were fused creating dendritoma vaccines for each patient. Phase I patients were vaccinated every 3 months with IL-2 given for 5 days after initial inoculation. Phase IIa patients were vaccinated every 6 weeks with IL-2 given on days 1, 3 and 5 after initial inoculation. Toxicity and clinical outcomes were assessed. Twenty-five patients were enrolled and inoculated. All dendritoma and IL-2 toxicities were |
| Databáze: | OpenAIRE |
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