Treatment of acute exacerbations of chronic bronchitis with clindamycin
| Autor: | A. H.G. Munro, F. Degnen, J. F. Munro, J. C. Gould, N. W.G. Ormonde |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
Chronic bronchitis medicine.medical_specialty Haemophilus Infections Time Factors Exacerbation Penicillin Resistance Administration Oral Microbial Sensitivity Tests medicine.disease_cause Pneumococcal Infections Haemophilus influenzae fluids and secretions Internal medicine Haemophilus medicine Humans Bronchitis Physical Therapy Modalities Aged biology business.industry Clindamycin Sputum General Medicine medicine.disease biology.organism_classification respiratory tract diseases Pneumococcal infections Streptococcus pneumoniae Acute Disease Chronic Disease Immunology Ampicillin Female medicine.symptom business medicine.drug |
| Zdroj: | Current Medical Research and Opinion. 1:390-394 |
| ISSN: | 1473-4877 0300-7995 |
| DOI: | 10.1185/03007997309111699 |
| Popis: | SummaryTwenty-six patients with acute exacerbations of chronic bronchitis requiring admission to hospital were treated with clindamycin 300 mg. or 450 mg. 6-hourly for 10 days to 3 weeks. Four were withdrawn because of side-effects. In 8 of the 22 completing the study, pneumococci were present in the pre-treatment sputum. With treatment, the organism was eradicated within 24 hours and in 5, the sputum became mucoid. All improved clinically although Haemophilus influenzae organisms were isolated at some stage from the sputum of all but one of these patients. Only 1 of the 14 whose sputum yielded predominantly haemophilus without pneumococci achieved sputum conversion, only 5 improved clinically and 3 deteriorated considerably in spite of intensive physiotherapy. Bacteriological eradication of Haemophilus influenzae did not occur when in vitro testing suggested sensitivity.It is concluded that clindamycin fails to eradicate Haemophilus influenzae from the sputum of patients with acute exacerbation of chroni... |
| Databáze: | OpenAIRE |
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