Dual Responsive, Stabilized Nanoparticles for Efficient In Vivo Plasmid Delivery
| Autor: | Ian W. Andrews, Don O. Maris, Drew L. Sellers, Hua Wei, David S.H. Chu, Lisa R. Volpatti, Suzie H. Pun, Ashton S. Hemphill, Leslie W. Chan, Philip J. Horner |
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| Rok vydání: | 2013 |
| Předmět: |
Small interfering RNA
Polymers Surface Properties Nanotechnology Endosomes Computational biology Transfection Article Catalysis Viral vector Plasmid Drug Stability Microscopy Electron Transmission In vivo Humans RNA Small Interfering Drug Carriers Chemistry Immunogenicity Gene Transfer Techniques General Chemistry General Medicine Endocytosis Nucleic acid Nanoparticles Drug carrier Hydrophobic and Hydrophilic Interactions HeLa Cells Plasmids |
| Zdroj: | Angewandte Chemie. 125:5485-5489 |
| ISSN: | 0044-8249 |
| Popis: | Nucleic acid-based therapeutics, including plasmid DNA (pDNA) and small interfering RNA (siRNA), have been considered highly promising strategies to treat a gamut of diseases.[1] Successful nucleic acid delivery relies on the development of safe and efficient delivery vectors. Viral vectors have dominated as the delivery vehicles used in clinical trials but their progress has been hampered by their immunogenicity, safety risks and high manufacturing cost.[2] Therefore, the use of non-viral vectors such as cationic polymer-based vectors that offer advantages over viral vectors in these aspects has attracted broad attention.[3-4] |
| Databáze: | OpenAIRE |
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