Effect of microspheres in intra-arterial chemotherapy. A study of arterio-venous shunting and passage of a labelled marker
| Autor: | Leif Håkansson, John Svedberg, Olallo Morales, Hans Starkhammar |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Drug Cancer Research medicine.medical_treatment media_common.quotation_subject Intra arterial chemotherapy Pharmacology Mitomycins Microsphere Humans Medicine Technetium Tc 99m Aggregated Albumin Aged media_common Chemotherapy Degradable starch microspheres business.industry Liver Neoplasms Angiography Starch Middle Aged Microspheres Shunting Drug concentration Injections Intra-Arterial Oncology Anesthesia business Technetium-99m Liver Circulation |
| Zdroj: | Medical Oncology and Tumor Pharmacotherapy. 4:87-96 |
| ISSN: | 0736-0118 |
| DOI: | 10.1007/bf02934945 |
| Popis: | Degradable starch microspheres (DSM) mixed and injected with a cytostatic drug might improve intra-arterial chemotherapy by increasing the local drug concentration. Several factors are of importance for an optimal effect of the microspheres, e.g. size and vascularity of the tumour, arterial blood flow and arterio-venous shunts. Therefore, the dose of DSM has to be individualized. A method for continuous monitoring of the effect of DSM was developed. A radiolabelled marker was injected intra-arterially mixed with DSM and mitomycin C. Two kinetic parameters--Passing Fraction and Marker Flow Rate--were found to be influenced by the microspheres and thus seemed to be useful for monitoring the DSM-treatment. Arterio-venous shunting was measured as passage of 99Tcm-labelled macroaggregated albumin through the liver to the lungs. Significant increase of shunting after injection of DSM was demonstrated in 15 out of 19 patients. Almost no effect of the microspheres was seen in patients with marked arterio-venous shunting or minimal reduction of the marker flow rate, but in others the passage of the labelled marker could generally be significantly reduced. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|