Neurosurgical follow-up and treatment of a series of 26 WHO grade III meningiomas
Autor: | Murat Şakir Ekşi, Mustafa Güdük, Baran Bozkurt, M. Necmettin Pamir, Murat İmre Usseli, Ayça Erşen Danyeli |
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Rok vydání: | 2021 |
Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment World Health Organization Meningioma Papillary Meningioma Physiology (medical) Statistical significance otorhinolaryngologic diseases medicine Meningeal Neoplasms Humans neoplasms Aged Retrospective Studies Chemotherapy Grade III Meningioma business.industry Standard treatment General Medicine Who grade Middle Aged medicine.disease nervous system diseases Radiation therapy Treatment Outcome Neurology Surgery Female Neurology (clinical) Radiology Neoplasm Recurrence Local business Follow-Up Studies |
Zdroj: | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 91 |
ISSN: | 1532-2653 |
Popis: | Meningiomas are the most common primary intracranial tumors. They have three pathologic grades. Surgical resection aiming Simpson I resection is the standard treatment for meningiomas. Radiotherapy and Gamma Knife radiosurgery are the main adjuvant and salvage treatments. Chemotherapy has limited use. Grade II, and III meningiomas have a higher recurrence rate, and adjuvant radiotherapy is usually the standard treatment for grade III meningiomas. In this paper, we analyzed our meningioma series of 1401 patients and presented the treatment and follow-up results of 26 grade III meningioma cases. Median follow-up of grade III meningiomas was 40.5 (range, 1–154) months. The mean age of patients was 51.7 ± 15.7 years; 12 of them were female and 14 were male (female/male ratio = 0.9). The median progression-free survival (PFS) of them was 22 months, and overall survival (OS) was 62 months. Meningiomas with gross total resection (GTR), non-skull base meningiomas, and primary grade III meningiomas had longer PFS, while meningiomas with GTR, non-skull base meningiomas, and primary meningiomas had longer OS with a statistical significance. |
Databáze: | OpenAIRE |
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