Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists

Autor:	Huizhong Gu, Dennis E. Busler, Tao Guo, Doug W. Hobbs, Laura L. Rokosz
Rok vydání:	2007
Předmět:	Food intake medicine.medical_specialty Tetrahydronaphthalenes Melanin-concentrating hormone Ratón Clinical Biochemistry Pharmaceutical Science CHO Cells Binding Competitive Biochemistry Mice Structure-Activity Relationship chemistry.chemical_compound Cricetulus Cricetinae Internal medicine Drug Discovery medicine Deficient mouse Animals Humans Urea Tissue Distribution Receptors Somatostatin Tetralin Receptor Molecular Biology Mice Knockout Organic Chemistry Antagonist respiratory system In vitro Rats Endocrinology chemistry Drug Design Molecular Medicine hormones hormone substitutes and hormone antagonists
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 17:1718-1721
ISSN:	0960-894X
Popis:	Melanin concentrating hormone (MCH) plays an important role in the regulation of food intake and energy balance in mammals. MCH-1 receptor (MCH1R) deficient mice are lean and resistant to diet-induced obesity. As such, MCH1R antagonists are believed to have potential as possible treatments for obesity. The discovery of a novel class of tetralin ureas as potent MCH1R antagonists is described herein.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85cf5f3987c0a1578a3f1773d6d63ae3 https://doi.org/10.1016/j.bmcl.2006.12.080 Zobrazit plný text záznamu Full Text from ScienceDirect