New Cycloartanol Sulfates from the Alga Tydemania expeditionis: Inhibitors of the Protein Tyrosine Kinase pp60v-src

Autor:	Meledath Govindan, Syed A. Abbas, Doris L. Slate, Francis J. Schmitz, Jacqueline S. Papkoff, Rita H. Lee
Rok vydání:	1994
Předmět:	Magnetic Resonance Spectroscopy Pharmaceutical Science Fractionation Spectrometry Mass Fast Atom Bombardment Pharmacognosy Oncogene Protein pp60(v-src) Analytical Chemistry Chlorophyta Drug Discovery Protein kinase A Cells Cultured Pharmacology chemistry.chemical_classification biology Organic Chemistry Phytosterols Tydemania expeditionis biology.organism_classification Triterpenes Enzyme Avian Sarcoma Viruses Complementary and alternative medicine Biochemistry chemistry Enzyme inhibitor biology.protein Molecular Medicine Drug Screening Assays Antitumor Tyrosine kinase Proto-oncogene tyrosine-protein kinase Src
Zdroj:	Journal of Natural Products. 57:74-78
ISSN:	1520-6025 0163-3864
DOI:	10.1021/np50103a010
Popis:	Bioactivity-directed fractionation of the extracts of the green alga Tydemiana expeditionis using the protein tyrosine kinase pp60 v-src led to the isolation of three new cycloartanol disulfates, 1-3, which show modest inhibition of this enzyme. The structures were deduced by spectroscopic methods
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85cec26c5b0ae07185200831a86db4ff https://doi.org/10.1021/np50103a010 Zobrazit plný text záznamu