Pharmacological Approaches to the Treatment of Intermittent Claudication???
| Autor: | E. G. Bevan, P. C. Waller, L. E. Ramsay |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Vasodilator Agents Pentoxifylline Pharmacotherapy Older patients medicine Humans Pharmacology (medical) Intensive care medicine Aged Randomized Controlled Trials as Topic business.industry Anticoagulants Publication bias Intermittent Claudication Naftidrofuryl Intermittent claudication Physical therapy Life expectancy Female Geriatrics and Gerontology medicine.symptom Claudication business medicine.drug |
| Zdroj: | Drugs & Aging. 2:125-136 |
| ISSN: | 1170-229X |
| DOI: | 10.2165/00002512-199202020-00006 |
| Popis: | Intermittent claudication is a common condition of the elderly, occurring in 3 to 20% of individuals over the age of 65 years. Although local disease is usually benign, life expectancy in patients with intermittent claudication is reduced by approximately 10 years due to associated cardiovascular mortality. Several classes of drugs have been used in intermittent claudication, but clinical studies evaluating their efficacy leave much to be desired. Pentoxifylline (oxpentifylline), a rheological agent, and naftidrofuryl, an enhancer of aerobic metabolism, are the 2 most widely investigated and utilised drugs. The combined results of 10 placebo-controlled studies with pentoxifylline and 4 with naftidrofuryl estimate increases in claudication distances of 51 and 42%, respectively. How-† The views expressed in this article are those of the authors and should not be taken to represent the official view of the UK Medicines Control Agency. ever, due to publication bias, these figures are probably overestimates of the true benefit from treatment with these drugs. It is likely that any benefit from pentoxifylline or naftidrofuryl is small and of little clinical importance. The suggestion that naftidrofuryl has greater efficacy in older patients remains unproven. Other classes of drugs including vasodilators, antiplatelet drugs, anticoagulants and prostaglandins have not been shown to be effective. Only 2 approaches to the management of intermittent claudication have been shown convincingly to be of benefit: stopping smoking and exercising regularly. |
| Databáze: | OpenAIRE |
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