Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat

Autor: Nicolas Flamand, Benoît Lamarche, Frédéric Raymond, Julie Perron, Lydiane Parent, Vincenzo Di Marzo, Alain Veilleux, Gabrielle Rochefort, Sébastien Lacroix, Cyril Martin, Sophie Castonguay-Paradis
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Mediterranean diet
Adipose tissue
lcsh:Medicine
Gut flora
Diet
Mediterranean
chemistry.chemical_compound
0302 clinical medicine
Tandem Mass Spectrometry
Body Fat Distribution
lcsh:Science
Phylogeny
Aged
80 and over
2. Zero hunger
chemistry.chemical_classification
education.field_of_study
Multidisciplinary
Microbiota
Fatty Acids
Anandamide
Middle Aged
Endocannabinoid system
Healthy Volunteers
3. Good health
nutrition
Female
Adult
medicine.medical_specialty
Polyunsaturated Alkamides
Population
Arachidonic Acids
Biology
Article
Glycerides
Young Adult
03 medical and health sciences
Internal medicine
medicine
Humans
Obesity
education
Aged
Bacteria
lcsh:R
Fatty acid
endocannabinoid
biology.organism_classification
Dietary Fats
Gastrointestinal Microbiome
Oleic acid
Cross-Sectional Studies
Metabolism
030104 developmental biology
Endocrinology
chemistry
nervous system
lcsh:Q
Energy Metabolism
030217 neurology & neurosurgery
Chromatography
Liquid
Endocannabinoids
Zdroj: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific reports (Nature Publishing Group) 10 (2020). doi:10.1038/s41598-020-72861-3
info:cnr-pdr/source/autori:Castonguay-Paradis, Sophie; Lacroix, Sebastien; Rochefort, Gabrielle; Parent, Lydiane; Perron, Julie; Martin, Cyril; Lamarche, Benoit; Raymond, Frederic; Flamand, Nicolas; Di Marzo, Vincenzo; Veilleux, Alain/titolo:Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat/doi:10.1038%2Fs41598-020-72861-3/rivista:Scientific reports (Nature Publishing Group)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:10
Scientific Reports
ISSN: 2045-2322
Popis: The endocannabinoidome encompasses several fatty acid (FA)-derived mediators, including the endocannabinoid anandamide (AEA) and 2-arachidonoyl-glycerol (2-AG), which served as targets for anti-obesity drug development, and their congener N-acyl-ethanolamines (NAEs) and 2-monoacyl-glycerols (2‑MAGs), which are involved in food intake and energy metabolism. Body weight and fat distribution have been suggested as determinants of peripheral endocannabinoid levels. We aimed at investigating factors, beyond body fat composition, that are associated with circulating NAE and 2-MAG levels in a heterogeneous human population. Plasma NAEs and 2-MAGs were measured using LC–MS/MS in a cross-sectional sample of healthy men and women (n = 195) covering a wide range of BMI and individuals before and after a 2-day Mediterranean diet (n = 21). Circulating levels of all 2-MAGs and NAEs, other than N-oleoyl-ethanolamine (OEA), correlated with body fat mass and visceral adipose tissue (0.26 Veillonellaceae, Peptostreptococcaceae and Akkermansiaceae) were associated with variations in most NAEs or omega-3-FA-derived 2‑MAGs, independently of fat mass and dietary FA intake. Finally, a 2-day Mediterranean diet intervention increased circulating levels of NAEs and 2-MAGs in agreement with changes in FA intake (p
Databáze: OpenAIRE
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