The protective effects of ketamine and propofol in obstructive jaundice: an experimental study
| Autor: | Hafize Öksüz, Z. Doğan, Huseyin Yildiz, Ertan Bulbuloglu, Bulent Kantarceken, Ergul Belge Kurutas, Nimet Senoglu, Harun Ciralik, Ismail Coskuner, Emin Silay, Ali Cetinkaya, Mehmet Fatih Yuzbasioglu |
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| Přispěvatelé: | BÜLBÜLOĞLU, ERTAN |
| Rok vydání: | 2012 |
| Předmět: |
Male
Economics and Econometrics Pentobarbital medicine.disease_cause Fentanyl chemistry.chemical_compound Malondialdehyde Materials Chemistry Media Technology Animals Medicine Ketamine Rats Wistar Propofol Anesthetics Dissociative Common bile duct Superoxide Dismutase business.industry Bile duct Forestry Catalase Rats Jaundice Obstructive Oxidative Stress medicine.anatomical_structure Liver chemistry Anesthesia business Anesthetics Intravenous Oxidative stress medicine.drug |
| Zdroj: | Bratislava Medical Journal. 113:139-144 |
| ISSN: | 1336-0345 |
| Popis: | OBJECTIVE In this study, we investigated the protective effects of frequently used intravenous anesthetics (ketamine, propofol, thiopental, and fentanyl) in oxidative stress in a rat liver model of obstructive jaundice. MATERIALS AND METHODS Thirty-two Wistar albino rats were divided into four groups in a randomized fashion. All rats were subjected to laparotomy, common bile duct ligation and severance on day 0. Following 7 days, laparotomy was again performed using ketamine, propofol, pentobarbital, or fentanyl anesthesia. After 2 hours, the animals were sacrificed and tissue specimens were acquired for histopathological scoring and determination of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activities. RESULTS All rats demonstrated enlargement in the bile duct, obstructive jaundice, and histopathologic ductal proliferation. MDA and SOD levels were significantly lower in the ketamine group compared with the thiopental and fentanyl groups. CAT was significantly increased in the ketamine group compared with the other groups. The best portal polymorphonuclear leukocyte and necrosis scores were in the ketamine group, but this difference was not statistically significant ( p=0.07). CONCLUSION Ketamine and propofol were observed to cause the least amount of oxidative stress in this rat model of induced oxidative stress generated by ligation of the common bile duct. This experiment is the first study on this subject in the literature (Tab. 3, Ref. 65). |
| Databáze: | OpenAIRE |
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