Prevalence of Cardiovascular Events in Patients with Autosomal Dominant Polycystic Kidney Disease

Autor: Oleksandra Tkachenko, Berenice Reed, Xiang-Dong Yan, Kim Mc Fann, Imed Helal, Pamela Mettler, Robert W. Schrier
Rok vydání: 2012
Předmět:
Adult
Male
medicine.medical_specialty
Hypertension
Renal
Population
Heart Valve Diseases
Myocardial Infarction
030232 urology & nephrology
Autosomal dominant polycystic kidney disease
Hyperlipidemias
030204 cardiovascular system & hematology
urologic and male genital diseases
Article
03 medical and health sciences
0302 clinical medicine
Risk Factors
Diabetes mellitus
Internal medicine
Diabetes Mellitus
Prevalence
medicine
Humans
Myocardial infarction
Family history
education
Stroke
Aged
Peripheral Vascular Diseases
education.field_of_study
Vascular disease
business.industry
Data Collection
Incidence (epidemiology)
Smoking
Arrhythmias
Cardiac
Middle Aged
Polycystic Kidney
Autosomal Dominant
medicine.disease
Aneurysm
3. Good health
Cardiovascular Diseases
Nephrology
Cardiology
Female
business
Zdroj: American Journal of Nephrology. 36:362-370
ISSN: 1421-9670
0250-8095
DOI: 10.1159/000343281
Popis: Background: This study evaluates the prevalence of cardiovascular events in autosomal dominant polycystic kidney disease (ADPKD) patients. Methods: We distributed surveys to 1,439 subjects from our ADPKD research database. In total, 426 subjects completed and returned surveys; 7 of these were from children and were excluded from the study. Results: The patients who responded were female (63.2%), nonHispanic (88.1%) and white (93.6%). The mean age of the total group was 53.2 ± 13.7 years; 82.8% had a family history of ADPKD and 32.5% had reached end-stage renal disease (ESRD). With respect to cardiovascular risk factors, 86.6% were hypertensive with a mean age at diagnosis of 36.9 ± 12.9 years and hypertension was significantly more prevalent in males. In addition, 19.6% of the subjects were obese, 20.8% were smokers, 8.7% had diabetes, 45.7% had high cholesterol and 17.8% were sedentary. The most prevalent self-reported cardiovascular events were arrhythmias (25.9%), evidence of peripheral vascular disease (16.5%), heart valve problems (14.4%), cardiac enlargement (9.5%), stroke or cerebral bleeding (7.5%), myocardial infarction (6%) and brain aneurysm (5.0%). The most commonly used antihypertensive medications were renin-angiotensin inhibitors used by 75% of ADPKD patients. Older ADPKD patients and those at ESRD had a significantly higher incidence of cardiovascular events. Conclusion: These findings support the high prevalence of cardiovascular risk factors and events in ADPKD patients which contribute to a greater mortality risk. Due to the prevalence of cardiovascular risk factors in the ADPKD population, early diagnosis and clinical intervention are recommended.
Databáze: OpenAIRE
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