Antimalarial phenanthrene amino alcohols. 3. Halogen-containing 9-phenanthrenemethanols
| Autor: | Masafu Shinbo, Andrew J. Saggiomo, Keiichi Tanabe, H. Otomasu, David Goff, E. H. Chen, Edward A. Nodiff, Atsuto Kozuka, M. P. Tyagi, B. L. Verma |
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| Rok vydání: | 1975 |
| Předmět: |
inorganic chemicals
Malaria Avian biology Chemistry Stereochemistry Plasmodium berghei Phenanthrene Phenanthrenes biology.organism_classification Amino Alcohols Malaria chemistry.chemical_compound Antimalarials Mice Structure-Activity Relationship Halogens parasitic diseases Drug Discovery Halogen Molecular Medicine Organic chemistry Animals Chickens |
| Zdroj: | Journal of medicinal chemistry. 18(10) |
| ISSN: | 0022-2623 |
| Popis: | A series of new 9-phenanthrene amino alcohols has been prepared in which each compound bears from one to five halogen or halogen-containing moieties. A number of these compounds are extremely active against Plasmodium berghei in the mouse. Some structural requirements for optimal efficacy are considered. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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