PUMA-mediated tumor suppression: A tale of two stories
| Autor: | Andreas Villunger, Verena Labi |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Cell type
DNA damage Apoptosis Biology medicine.disease_cause Cell Line law.invention Mice law Proto-Oncogene Proteins Puma medicine Animals Humans Scattering Radiation Molecular Biology Cyclin-Dependent Kinase Inhibitor p16 Mice Knockout Cell Biology Hematopoietic Stem Cells biology.organism_classification Haematopoiesis Proto-Oncogene Proteins c-bcl-2 Immunology Cancer research Suppressor Tumor Suppressor Protein p53 biological phenomena cell phenomena and immunity Stem cell Apoptosis Regulatory Proteins Carcinogenesis DNA Damage Developmental Biology |
| Zdroj: | Cell Cycle. 9:4269-4275 |
| ISSN: | 1551-4005 1538-4101 |
| Popis: | Several recent studies provided evidence that PUMA, a pro-apoptotic member of the BH3-only protein subgroup of the Bcl-2 family, is critical for restricting survival and recovery of different cell types, including those of the hematopoietic system, after γ-irradiation (IR)-triggered DNA damage. According to its pro-apoptotic function downstream of p53, PUMA is considered to act as a tumor suppressor. While this expectation was met in a model of oncogene-driven lymphomagenesis or carcinogen-driven tumor formation in the gut, studies on IR-driven tumor formation revealed surprising new insights into the role of p53-triggered and PUMA-mediated apoptosis in tumorigenesis and stem cell homeostasis. |
| Databáze: | OpenAIRE |
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