Effects of Erythrosine on Neural Tube Development in Early Chicken Embryos
| Autor: | Erhan Emel, Mehmet Sar, Aysegul Esen Aydin, Talat Cem Ovalioglu, Sema Arslan, Gokhan Canaz, Aysegul Ozdemir Ovalioglu |
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| Rok vydání: | 2020 |
| Předmět: |
Neural Tube
animal structures medicine.medical_treatment Sodium Embryonic Development chemistry.chemical_element Chick Embryo Iodine Andrology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Neural Tube Defects Saline Incubation Fluorescent Dyes Neural tube defect business.industry Neural tube Abnormalities Drug-Induced Embryo Erythrosine medicine.disease medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis embryonic structures Surgery Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | World Neurosurgery. 134:e822-e825 |
| ISSN: | 1878-8750 |
| DOI: | 10.1016/j.wneu.2019.11.017 |
| Popis: | Objective Erythrosine (E127), a synthetic food dye containing iodine and sodium, has often been used inside packaged foods and beverages in Turkey and many other countries. We evaluated the effects of erythrosine on neural tube development in early-stage chicken embryos. Methods The study included 4 groups, with a total of 80 embryos: a control group, a normal saline group, a half-dose group, and a high-dose group. After 30 hours of incubation, saline and erythrosine solution was injected under the embryonic discs. At the end of 72 hours, the embryos were excised and evaluated macroscopically and histopathologically. Results Neural tube defects were detected in the erythrosine-administered groups with statistically significant differences. In contrast, the embryos in the control and saline groups displayed normal development. Conclusions Erythrosine increased the risk of neural tube defects in early-stage chicken embryos, even at half of the approved dose. |
| Databáze: | OpenAIRE |
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