Comparative effects of prenatal cocaine, alcohol, and undernutrition on maternal/fetal toxicity and fetal body composition in the Sprague-Dawley rat with observations on strain-dependent differences
| Autor: | Marappa G. Subramanian, Connie A. Morbach, Michael W. Church |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Body water Drinking Weight Gain Toxicology Rats Sprague-Dawley Eating Embryonic and Fetal Development Cellular and Molecular Neuroscience Cocaine Species Specificity Developmental Neuroscience Pregnancy Internal medicine medicine Animals Maternal-Fetal Exchange Analysis of Variance Fetus Dose-Response Relationship Drug Ethanol business.industry medicine.disease Teratology Nutrition Disorders Rats Endocrinology Toxicity Body Composition Gestation Female Diuretic medicine.symptom business Weight gain |
| Zdroj: | Neurotoxicology and Teratology. 17:559-567 |
| ISSN: | 0892-0362 |
| DOI: | 10.1016/0892-0362(95)00016-k |
| Popis: | Pregnant rats received either 20, 30, 40, or 50 mg/kg cocaine HCl (SC) twice daily from gestation days 7 through 19. Pair-fed and untreated control groups and a group receiving 3.0 g/kg alcohol (PO) twice daily served as comparison groups. Females were sacrificed on gestation day 20 and the fetuses examined. Maternal weight gain and food consumption showed dose-dependent decreases. Maternal water consumption, by contrast, was significantly increased in the cocaine-treated animals and may reflect a diuretic effect. The maternal mortality rates in Sprague-Dawley rats were less than in two strains of Long-Evans rats, suggesting important strain-dependent differences in susceptibility to cocaine toxicity. Cocaine caused a significant dose-dependent decrease in fetal weights. Physical anomalies in the cocaine-exposed and alcohol-exposed fetuses included occasional hemorrhaging, edema, anophthalmia, and limb reduction. Despite increased maternal water consumption by cocaine-treated dams, there were no increases in fetal body water content. There were, however, significant decreases in fetal body fat content in the pair-fed, alcohol-treated, and two highest cocaine-treated groups. |
| Databáze: | OpenAIRE |
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