Role of ADHD symptoms as a contributing factor to obesity in patients with MC4R mutations
| Autor: | Grazia Giana, Samuele Cortese, Adriana Lo-Castro, Marie Christine Mouren, Paolo Curatolo, Silvia Giovinazzo, Diane Purper-Ouakil, Maria Cristina Porfirio |
|---|---|
| Přispěvatelé: | Università degli Studi di Roma Tor Vergata [Roma], Service de psychopathologie de l'enfant et de l'adolescent, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Gene mutation Monogenic Obesity Overweight Bioinformatics medicine.disease_cause Models Biological 03 medical and health sciences 0302 clinical medicine Reward mental disorders medicine Genetic predisposition Humans In patient Obesity Adhd symptoms Psychiatry 030304 developmental biology 0303 health sciences Mutation business.industry Feeding Behavior General Medicine medicine.disease Settore MED/39 - Neuropsichiatria Infantile 3. Good health Attention Deficit Disorder with Hyperactivity Receptor Melanocortin Type 4 medicine.symptom business 030217 neurology & neurosurgery [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Medical Hypotheses Medical Hypotheses, Elsevier, 2015, 84 (1), pp.4-7. ⟨10.1016/j.mehy.2014.11.004⟩ |
| ISSN: | 0306-9877 |
| Popis: | International audience; Besides the crucial role of genetic susceptibility in the development of early-onset obesity, it has been shown that feeding behavior could contribute to increased body weight. A significant association between obesity/overweight and ADHD has been reported, suggesting that these two conditions, despite their heterogeneity, might share common molecular pathways. Although the co-occurrence of obesity and ADHD is increasingly supported by empirical evidence, the complex pathogenetic link between these two conditions is still unclear. Here, we focus on the relationship between MC4R gene mutations and ADHD in children with early-onset obesity. Mutations in the gene MC4R lead to the most common form of monogenic obesity. We hypothesize that dysregulated eating behavior in a subset of patients with MC4R mutation might be due to comorbid ADHD symptoms, underpinned by abnormal reward mechanisms. Therefore, we speculate that it is possible to prevent obesity in a subset of patients with MC4R mutation, even if these patients are genetically programmed to "be fat", via an appropriate treatment of ADHD symptoms. We hope that our paper will stimulate further studies testing if the early screening for ADHD symptoms and their appropriate treatment may be an effective way to prevent obesity in a subset of children with MC4R mutation. |
| Databáze: | OpenAIRE |
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