Hypertrophic osteoarthropathy effectively treated with zoledronic acid
| Autor: | Douglas A. Nelson, Melissa M. King |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Pulmonary and Respiratory Medicine
Cancer Research medicine.medical_specialty Lung Neoplasms Analgesic Zoledronic Acid Spinal osteoarthropathy medicine Carcinoma Humans Lung cancer Bone Density Conservation Agents Diphosphonates business.industry Digital Clubbing Osteoarthropathy Secondary Hypertrophic Imidazoles Middle Aged medicine.disease Dermatology Hypertrophic osteoarthropathy Surgery Zoledronic acid Carcinoma Bronchogenic Oncology Adenocarcinoma Female business medicine.drug |
| Zdroj: | Clinical lung cancer. 9(3) |
| ISSN: | 1525-7304 |
| Popis: | Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by digital clubbing, arthralgias, and tissue swelling and is frequently described in association with bronchogenic carcinoma. The associated pain can be disabling, and symptoms are often resistant to conventional analgesic medications. We present a patient with HOA of the lower extremities and wrists that developed after bronchogenic carcinoma. The pain and swelling completely resolved after a single administration of 4 mg of zoledronic acid. The proposed pathogenesis of HOA and the mechanisms by which bisphosphonates might alleviate symptoms are reviewed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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