Differential expression profiling of head and neck squamous cell carcinoma (HNSCC)
| Autor: | L. Bracco, F Lemaire, Julia Young, Régine Millon, Inès Schultz, Anne Cromer, Joseph Abecassis, Changqi Zhao, Christine Wasylyk, D Melle, Bohdan Wasylyk, Danièle Muller, P. Marchal |
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| Rok vydání: | 2003 |
| Předmět: |
Keratinocytes
Male Cancer Research Pathology medicine.medical_specialty DNA Complementary Cellular differentiation Biology Genome Polymerase Chain Reaction functional classes medicine Humans Gene Aged DNA Primers ‘unknown’ genes Differential display Neovascularization Pathologic Gene Expression Profiling Molecular and Cellular Pathology hypopharynx Cancer biomarkers Cell Differentiation Middle Aged medicine.disease Blotting Northern Head and neck squamous-cell carcinoma Gene expression profiling Gene Expression Regulation Neoplastic Oncology Epidermoid carcinoma Head and Neck Neoplasms Cancer research Carcinoma Squamous Cell Female virtual Northern pharmaceutical targets |
| Zdroj: | British Journal of Cancer |
| ISSN: | 0007-0920 |
| Popis: | Head and neck squamous cell carcinoma (HNSCC) is the fifth most common cancer in men with an incidence of about 780000 new cases per year worldwide and a poor rate of survival. There is a need for a better understanding of HNSCC, for the development of rational targeted interventions and to define new prognostic or diagnostic markers. To address these needs, we performed a large-scale differential display comparison of hypopharyngeal HNSCCs against histologically normal tissue from the same patients. We have identified 70 genes that exhibit a striking difference in expression between tumours and normal tissues. There is only a limited overlap with other HNSCC gene expression studies that have used other techniques and more heterogeneous tumour samples. Our results provide new insights into the understanding of HNSCC. At the genome level, a series of differentially expressed genes cluster at 12p12-13 and 1q21, two hotspots of genome disruption. The known genes share functional relationships in keratinocyte differentiation, angiogenesis, immunology, detoxification, and cell surface receptors. Of particular interest are the 13 'unknown' genes that exist only in EST, theoretical cDNA and protein databases, or as chromosomal locations. The differentially expressed genes that we have identified are potential new markers and therapeutic targets. |
| Databáze: | OpenAIRE |
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