Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-Proteinase: solid-Phase synthesis of ornithine analogues

Autor:	Harold E. Van Wart, Keith A. M. Walker, Leslie A. Robinson, Nancy G. J. Delaet, Robert L. Martin, Sharon M. Dankwardt, Christine S. Chan
Rok vydání:	2001
Předmět:	Ornithine Stereochemistry Clinical Biochemistry Pharmaceutical Science Hydroxamic Acids Biochemistry Chemical synthesis Bone Morphogenetic Protein 1 chemistry.chemical_compound Solid-phase synthesis Drug Discovery Amino Acids Enzyme Inhibitors Molecular Biology chemistry.chemical_classification Sulfonamides Hydroxamic acid biology Organic Chemistry Metalloendopeptidases Sulfonamide Amino acid Procollagen peptidase chemistry Enzyme inhibitor Bone Morphogenetic Proteins biology.protein Molecular Medicine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 11:2085-2088
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(01)00384-5
Popis:	A discussion of the solid-phase synthesis of ornithine derived sulfonamide hydroxamic acids is illustrated. These analogues are shown to be potent, non-peptide inhibitors of procollagen C-proteinase (PCP).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c06e2ed0aed2b14903395e61b042b9 https://doi.org/10.1016/s0960-894x(01)00384-5 Zobrazit plný text záznamu Full Text from ScienceDirect