Application of laboratory and digital techniques for visual enhancement during the ultrastructural assessment of cilia

Autor:	Josef Schroeder
Rok vydání:	2017
Předmět:	0301 basic medicine Diagnostic electron microscopy Pathology medicine.medical_specialty Axoneme Tissue Fixation medicine.diagnostic_test Kartagener Syndrome Cilium Biology medicine.disease Pathology and Forensic Medicine 03 medical and health sciences Imaging Three-Dimensional 030104 developmental biology Microscopy Electron Transmission Structural Biology Biopsy Image Processing Computer-Assisted Ultrastructure medicine Humans Cilia Analysis tools Primary ciliary dyskinesia
Zdroj:	Ultrastructural Pathology. 41:399-407
ISSN:	1521-0758 0191-3123
DOI:	10.1080/01913123.2017.1363335
Popis:	Routine diagnostic electron microscopy of primary ciliary dyskinesia (PCD) is based on the findings of ultrastructural defects of axonemal components. Assessment of the typical abnormalities can be enhanced by improving the sample preservation status using tannic acid (TA) as additive in the biopsy fixation or processing steps. Another option is the implementation of computer-assisted image analysis tools. Advancements in high-resolution 3D visualization of the axonemal structure have been noted, with great potential for the future diagnosis of inherited cilia disorders.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c06c322f156fa861bc22c53e2cdb11 https://doi.org/10.1080/01913123.2017.1363335 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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