CXCL13 chemokine as a promising biomarker to diagnose neurosyphilis in HIV-negative patients
| Autor: | Wei-Hong Zheng, Zhaoji Liu, Jiang-Hua Yan, Ning-Ning Zhang, Hui-Lin Zhang, Feng Peng, Yan-Li Zeng, Li–Li Liu, Yiqiang Lin, Chao-Ning Zou |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Multidisciplinary Treponema Receiver operating characteristic biology business.industry Research 030106 microbiology CXCL13 medicine.disease biology.organism_classification Neurosyphilis 03 medical and health sciences Cerebrospinal fluid Neuroinflammation Immunology medicine Biomarker (medicine) Syphilis Treponema pallidum business |
| Zdroj: | SpringerPlus |
| ISSN: | 2193-1801 |
| DOI: | 10.1186/s40064-016-2462-4 |
| Popis: | Background Chemokine ligand 13 (CXCL13) is believed to play a role in the recruitment of B cells in the central nervous system during neuroinflammation. Neurosyphilis is a group of clinical syndromes of the central nervous system caused by Treponema pallidum (T. pallidum) infection. The relationship between CXCL13 and neurosyphilis still needs further study. In our study, CSF and serum CXCL13 concentrations were detected among 40 neurosyphilis patients, 31 syphilis/non-neurosyphilis patients, 26 non-syphilis/other central nervous system diseases patients. Serum CXCL13 concentrations were detected in 49 healthy persons. All enrolled persons were HIV-negative. Receiver operating characteristic (ROC) analysis was performed to determine the threshold value that could distinguish neurosyphilis from syphilis. Results We found that the CSF CXCL13 concentrations and CXCL13 quotient (QCXCL13) were significantly increased in neurosyphilis patients compared to syphilis/non-neurosyphilis (χ2 = 21.802, P |
| Databáze: | OpenAIRE |
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