Osteoarthritis of knee joint in metabolic syndrome
Autor: | Ola Gharbia, Reham M. Shaat, Abd El Moaty Ali Afifi, Yosra El Boghdadi, Mervat Mohammad El Eshmawy, Ola Ali El-Emam |
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Rok vydání: | 2018 |
Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty WOMAC Waist Knee Joint Osteoarthritis Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine Diabetes mellitus Prevalence medicine Humans National Cholesterol Education Program Abdominal obesity Metabolic Syndrome 030203 arthritis & rheumatology business.industry General Medicine Middle Aged Osteoarthritis Knee medicine.disease Radiography 030104 developmental biology Socioeconomic Factors Case-Control Studies Egypt Female medicine.symptom Metabolic syndrome business |
Zdroj: | Clinical Rheumatology. 37:2855-2861 |
ISSN: | 1434-9949 0770-3198 |
Popis: | Pathogenesis of osteoarthritis may have a systemic metabolic component. This study was undertaken to assess the prevalence of primary knee osteoarthritis (OA) in a sample of Egyptian patients with metabolic syndrome (MetS) and to examine the relationship of metabolic syndrome and its components with clinical, functional, and radiographic findings of knee OA. A total of 60 patients (55 females, 5 males) diagnosed as having MetS according to the National Cholesterol Education Program Adult Treatment Panel III (ATP III) criteria and 30 obese subjects without MetS (24 females, 6 males), serving as a control group, were included in this study. All participants had completed preliminary questionnaires, clinical and laboratory examinations, and an evaluation for radiographic knee OA. Scores from the Western Ontario and Mc-Master University (WOMAC) were used for the pain, stiffness, and disability assessments of OA patients. X-rays were classified according to the Kellgren–Lawrence (KL) radiographic rating scale. We tested the relationship of metabolic syndrome and its components with the WOMAC score and radiographic findings of knee OA after adjusting for BMI. The prevalence of OA was 83.3% in MetS group compared with 63.3% in control group (P = 0.034). MetS patients with OA had higher WOMAC score and radiographic grading than controls with OA (P = 0.034, 0.019). MetS patients with OA had more waist circumference (WC) (P = 0.022), and higher frequency of hypertension (HTN) and diabetes mellitus (DM) (P = 0.009, 0.002 respectively) than MetS patients without OA. There were significant associations of MetS, WC, HTN, DM, high TG, and low HDL with OA (P = 0.041, 0.007 |
Databáze: | OpenAIRE |
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